Gram-negative bacteremia is a devastating public health threat, with high mortality in
vulnerable populations and significant costs to the global economy. Concerningly, rates of …

Background Increasing rates of resistant and multidrug-resistant (MDR) P. aeruginosa in
hospitalized patients constitute a major public health threat. We present a systematic review …

Background Data on the use of ceftolozane-tazobactam and emergence of ceftolozane-
tazobactam resistance during multidrug resistant (MDR)-Pseudomonas aeruginosa …

The development of antimicrobial resistance among gram-negative pathogens has been
progressive and relentless. Pathogens of particular concern include extended-spectrum β …

Pseudomonas aeruginosa is among the leading causes of severe nosocomial infections,
particularly affecting critically ill and immunocompromised patients. Here we review the …

Despite concerns of nephrotoxicity, polymyxin antibiotics often remain the only susceptible
agents for multidrug-resistant (MDR) Gram-negative bacteria. Colistin has been more …

OBJECTIVE: To study the predictors of mortality among patients with multi-drug resistant
Gram negative (MDRGN) infections and the role of MDRGN bacteria in the outcome of such …

Abstract Background Multidrug-resistant Pseudomonas aeruginosa infections remain
common in hospitals worldwide. We investigated the outcomes associated with the use of …

ABSTRACT Relebactam (formerly MK-7655) is an inhibitor of class A and C β-lactamases,
including Klebsiella pneumoniae carbapenemase (KPC), and is currently in clinical …

Nephrotoxicity induced by antimicrobial or anticancer drugs is a serious clinical problem.
Megalin, an endocytic receptor expressed at the apical membranes of proximal tubules …