Neglected tropical diseases affect the lives of a billion people worldwide. Among them, the
parasitic infections caused by protozoan parasites of the Trypanosomatidae family have a …

In this study, we set out to create some new oxadiazole-thiadiazole fluorochromane hybrid
compounds 7a–7j and test them for their antioxidant properties. β-blockers drug-based 6 …

Herin we report the design, synthesis, full characterization and biological investigation of
new 15-LOX/COX dual inhibitors based on 1, 3-thiazolidin-4-one (15-lipoxygenase …

Broad-spectrum anti-infective chemotherapy agents with activity against Trypanosomes,
Leishmania, and Mycobacterium tuberculosis species were identified from a high …

Abstract Two series of novel 1, 2, 4-triazol-3-yl-thioacetamide 3a-b and 4a-b and 5-pyrazin-2-
yl-3H-[1, 3, 4] oxadiazole-2-thiones 9a-h were designed and synthesized. The compounds …

Introduction Trypanosomatidic parasitic infections in humans and animals caused by
Trypanosoma brucei, Trypanosoma cruzi, and Leishmania species pose a significant health …

Basing on a library of thiadiazole derivatives showing anti-trypanosomatidic activity, we
have considered the thiadiazoles opened forms and reaction intermediates …

2-Amino-benzo [d] thiazole was identified as a new scaffold for the development of improved
pteridine reductase-1 (PTR1) inhibitors and anti-trypanosomatidic agents. Molecular …

A novel organic acid–base-co-catalyzed conversion of styrylepoxides into [1, 1′-biaryl]-3-
carbaldehydes was realized under microwave irradiation. Styrylepoxides first underwent an …

The optimization of compounds with multiple targets is a difficult multidimensional problem
in the drug discovery cycle. Here, we present a systematic, multidisciplinary approach to the …