[HTML][HTML] Cisplatin-induced ototoxicity: From signaling network to therapeutic targets

X Wang, Y Zhou, D Wang, Y Wang, Z Zhou… - Biomedicine & …, 2023 - Elsevier
Administration of cisplatin, a common chemotherapeutic drug, has an inevitable side effect
of sensorineural hearing loss. The main etiologies are stria vascularis injury, spiral ganglion …

Drug‐induced ototoxicity: mechanisms, pharmacogenetics, and protective strategies

C Lanvers‐Kaminsky… - Clinical …, 2017 - Wiley Online Library
Drug ototoxicity limits the quality of life of patients after treatment, having serious
consequences, especially for psychosocial development of children. Although the ototoxicity …

PRDX1 activates autophagy via the PTEN-AKT signaling pathway to protect against cisplatin-induced spiral ganglion neuron damage

W Liu, L Xu, X Wang, D Zhang, G Sun, M Wang… - Autophagy, 2021 - Taylor & Francis
Spiral ganglion neurons (SGNs) are auditory neurons that relay sound signals from the inner
ear to the brainstem. The ototoxic drug cisplatin can damage SGNs and thus lead to …

Adolescent and young adult (AYA) oncology, version 2.2024, NCCN clinical practice guidelines in oncology

S Bhatia, AS Pappo, M Acquazzino… - Journal of the National …, 2023 - jnccn.org
This selection from the NCCN Guidelines for Adolescent and Young Adult (AYA) Oncology
focuses on considerations for the comprehensive care of AYA patients with cancer …

Global burden of hearing impairment and ear disease

K Graydon, C Waterworth, H Miller… - The Journal of …, 2019 - cambridge.org
BackgroundHearing loss can present at birth or be acquired as a result of illness, middle-ear
disease, injury, age, overuse of certain medications, and/or induced by exposure to …

Cisplatin-induced ototoxicity: updates on molecular targets

E Gentilin, E Simoni, M Candito, D Cazzador… - Trends in molecular …, 2019 - cell.com
Cis-diamminedichloridoplatinum (II)(cisplatin) is a chemotherapeutic drug currently
prescribed for the treatment of many types of human cancer, but its use is associated with …

Effects of sodium thiosulfate versus observation on development of cisplatin-induced hearing loss in children with cancer (ACCL0431): a multicentre, randomised …

DR Freyer, L Chen, MD Krailo, K Knight… - The Lancet …, 2017 - thelancet.com
Background Sodium thiosulfate is an antioxidant shown in preclinical studies in animals to
prevent cisplatin-induced hearing loss with timed administration after cisplatin without …

[HTML][HTML] Global burden of ototoxic hearing loss associated with platinum-based cancer treatment: A systematic review and meta-analysis

LK Dillard, L Lopez-Perez, RX Martinez… - Cancer …, 2022 - Elsevier
Platinum-based chemotherapeutic agents cisplatin and carboplatin are widely used in
cancer treatment worldwide and may result in ototoxic hearing loss. The high incidence of …

New treatment options for hearing loss

U Müller, PG Barr-Gillespie - Nature reviews Drug discovery, 2015 - nature.com
Hearing loss is the most common form of sensory impairment in humans and affects more
than 40 million people in the United States alone. No drug-based therapy has been …

Ototoxicity and cancer therapy

W Landier - Cancer, 2016 - Wiley Online Library
Ototoxicity is a well‐established toxicity associated with a subgroup of antineoplastic
therapies that includes platinum chemotherapy, radiation or surgery involving the ear and …