The discovery of cannabinoid receptors and subsequent identification of their endogenous
ligands (endocannabinoids) in early 1990s have greatly accelerated research on …

In this review we will critically assess the hypothesis that the reinforcing effect of virtually all
drugs of abuse is primarily dependent on activation of the mesolimbic dopamine system …

CB 1 cannabinoid receptors appear to mediate most, if not all of the psychoactive effects of
delta-9-tetrahydrocannabinol and related compounds. This G protein-coupled receptor has …

The involvement of dopamine in drug reinforcement is well recognized but its role in drug
addiction is much less clear. Imaging studies have shown that the reinforcing effects of drugs …

Imaging studies have provided evidence of how the human brain changes as an individual
becomes addicted. Here, we integrate the findings from imaging studies to propose a model …

The endogenous cannabinoid system is an ubiquitous lipid signalling system that appeared
early in evolution and which has important regulatory functions throughout the body in all …

Dopamine (DA) is a major catecholamine neurotransmitter in the mammalian brain that
controls neural circuits involved in the cognitive, emotional, and motor aspects of goal …

The endocannabinoid system consists of endogenous cannabinoids (endocannabinoids),
the enzymes that synthesize and degrade endocannabinoids, and the receptors that …

Cannabinoid type 1 receptors and transient receptor potential vanilloid type 1 channels
have been proposed to act as metabotropic and ionotropic receptors, respectively, for two …

Adenosine plays a very significant role in modulating striatal glutamatergic and
dopaminergic neurotransmission. In the present essay we first review the extensive …