Over the past decade, many studies have indicated that adolescence is a critical period of
brain development and maturation. The refinement and maturation of the central nervous …

Objectives The liberalisation of cannabis laws, the increasing availability and potency of
cannabis has renewed concern about the risk of psychosis with cannabis. Methods The …

Initiating drug use during adolescence increases the risk of developing addiction or other
psychopathologies later in life, with long-term outcomes varying according to sex and exact …

Abstract Δ9-tetrahydrocannabinol (THC) is the intoxicating constituent of cannabis and is
responsible for the drug's reinforcing effects. Retrospective human studies suggest that …

Substance use in adolescence is a known risk factor for the development of neuropsychiatric
and substance use disorders in adulthood. This is in part due to the fact that critical aspects …

The endocannabinoid system (ES) is a cell-signalling system widely distributed in biological
tissues that includes endogenous ligands, receptors, and biosynthetic and hydrolysing …

Nucleosomes composed of histone octamer and DNA are the basic structural unit in the
eukaryote chromosome. Under the stimulation of various factors, histones will undergo …

Migraine is a complex neurological disorder and a major cause of disability. A wide range of
different drug classes such as triptans, antidepressants, anticonvulsants, analgesics, and …

During adolescence, the brain continues to undergo vital developmental processes. In turn,
complex behavioral and cognitive skills emerge. Unfortunately, neurobiological …

Cannabis abuse is a common phenomenon among adolescents. The dominant
psychoactive substance in Cannabis sativa is tetrahydrocannabinol (THC). However, in the …