Image analysis using multiplex immunofluorescence (mIF) to detect different proteins in a
single tissue section has revolutionized immunohistochemical methods in recent years. With …

Purpose In colorectal cancer (CRC), whether the immune score can be used to predict the
clinical prognosis of the patient has not been completely established. Besides, the …

Background CD8+ T cell trafficking to the tumor site is essential for effective colorectal
cancer (CRC) immunotherapy. However, the mechanism underlying CD8+ T cell infiltration …

Colorectal cancer (CRC) represents a significant global health burden, with high incidence
and mortality rates worldwide. Recent progress in research highlights the distinct clinical …

Introduction The host anti-tumour inflammatory response is a strong prognostic indicator,
and tumour infiltrating lymphocytes (TILs) are believed to have a complimentary role …

Simple Summary The extracellular matrix surrounding or infiltrating tumor tissues, tumor
cells, endothelial cells, immune cells, fibroblasts, macrophages, as well as soluble …

Adaptive immune cells prevent solid tumor progression by targeting and killing tumor cells.
However, there are no comprehensive studies on peripheral circulating adaptive immune …

Purpose The aim of this study was to evaluate the Immunoscore (IS) methodology as a
prognostic marker of colorectal adenocarcinoma in Tunisian population. Tumor blocks were …

Colorectal cancer (CRC) is one of the most prevalent cancer types worldwide, with a high
mortality rate due to metastasis. The tumor microenvironment (TME) contains multiple …

Dendritic cells (DCs) are essential in antitumor immunity. In humans, three main DC subsets
are defined: two types of conventional DCs (cDC1s and cDC2s) and plasmacytoid DCs …