Crk family adaptors are widely expressed and mediate the timely formation of signal
transduction protein complexes upon a variety of extracellular stimuli, including various …

Protein–protein interactions occurring via the recognition of short peptide sequences by
modular interaction domains play a central role in the assembly of signalling protein …

Crosstalk mechanisms have not been studied as thoroughly as individual signaling
pathways. We exploit experimental and computational approaches to reveal how a …

The t (9; 22)(q34; q11) or Philadelphia chromosome creates a BCR–ABL1 fusion gene
encoding for a chimeric BCR–ABL1 protein. It is present in 3–4% of pediatric acute …

Introduction 3. Conventional and atypical sequence motifs 3.1. Canonical peptide motifs
recognized by the SH3 domains 3.2. Atypical SH3-binding motifs 3.3. The RxxK motif 4 …

Since their discovery a little more than a decade ago, the docking proteins of the Gab/DOS
family have emerged as important signalling elements in metazoans. Gab/DOS proteins …

Gab proteins, including mammalian Gab1, Gab2, Gab3, Drosophila DOS and
Caenorhabditis elegans Soc1, comprise a growing family of scaffolding/docking molecules …

The basic function of the Src homology 3 (SH3) domain is considered to be binding to
proline‐rich sequences containing a PxxP motif. Recently, many SH3 domains, including …

A critical event in T cell receptor (TCR)-mediated signaling is the recruitment of
hematopoietic-specific adaptor proteins that collect and transmit signals downstream of the …

The SH3 domain, which normally recognizes proline-rich sequences, has the potential to
bind motifs with an RxxK consensus. To explore this novel specificity, we have determined …