Renal fibrosis is the final pathological process common to any ongoing, chronic kidney
injury or maladaptive repair. It is considered as the underlying pathological process of …

Glomerular podocytes are highly specialized cells with a complex cytoarchitecture. Their
most prominent features are interdigitated foot processes with filtration slits in between …

First identified as cell cycle inhibitors mediating the growth inhibitory cues of upstream
signaling pathways, the cyclin-CDK inhibitors of the Cip/Kip family p21Cip1, p27Kip1, and …

The terminally differentiated podocyte, also called glomerular visceral epithelial cell, are
highly specialized cells. They function as a critical size and charge barrier to prevent …

The visceral glomerular epithelial cell, also called podocyte, is a terminally differentiated cell
that lines the outer aspect of the glomerular basement membrane (GBM). It therefore forms …

Interstitial fibrosis has a major role in the progression of renal diseases. Several animal
models are available for the study of renal fibrosis. The models of aminonucleoside-induced …

p27kip1 (p27) is a member of the universal cyclin-dependent kinase inhibitor (CDKI) family.
p27 expression is regulated by cell contact inhibition and by specific growth factors, such as …

Abstract Learning Objectives After completing this course, the reader will be able to:
Differentiate between the actions of oncogenes and tumor suppressor genes in the …

Unilateral ureteral obstruction is a popular experimental model of renal injury. However, the
study of the kidney response to urinary tract obstruction is only one of several advantages of …

Cyclin-dependent kinases (CDKs) regulate the cell division cycle, apoptosis, transcription
and differentiation in addition to functions in the nervous system. Deregulation of CDKs in …