Anxiety is experienced in response to threats that are distal or uncertain, involving changes
in one's subjective state, autonomic responses, and behavior. Defensive and physiologic …

The ability to adapt to dynamic environments requires tracking multiple signals with variable
sensory salience and fluctuating behavioral relevance. This complex process requires …

The amygdala and orbitofrontal cortex have been implicated in emotion. To understand
these regions better in humans, their effective connectivity with 360 cortical regions was …

The mediodorsal thalamus (MD) and anterior thalamic nuclei (ATN) are two adjacent brain
nodes that support our ability to make decisions, learn, update information, form and retrieve …

Executive control, the ability to organize thoughts and action plans in real time, is a defining
feature of higher cognition. Classical theories have emphasized cortical contributions to this …

All pathways targeting the thalamus terminate directly onto the thalamic projection cells. As
these cells lack local excitatory interconnections, their computations are fundamentally …

Degeneration of neurons and circuits across the striatum shows stereotyped time-course
and spatial topography patterns that are distinct for Huntington's disease, Parkinson's …

Non-human primate (NHP) models are essential for developing and translating new
treatments that target neural circuit dysfunction underlying human psychopathology. As a …

The reuniens nucleus (RE) is situated at the most ventral position of the midline thalamus. In
rats and mice RE is distinguished by bidirectional connections with the hippocampus and …

Appropriate expression of fear in the face of threats in the environment is essential for
survival. The sustained expression of fear in the absence of threat signals is a central …