Stem cells mechanosense the stiffness of their microenvironment, which impacts
differentiation. Although tissue hydration anti-correlates with stiffness, extracellular matrix …

The expanding interest in electrospinning fibers for bioengineering includes a significant
use of polyesters, including poly (ε-caprolactone)(PCL). This review summarizes literature …

Cell-matrix interactions have major effects upon phenotypic features such as gene
regulation, cytoskeletal structure, differentiation, and aspects of cell growth control …

Abnormal vascularization of malignant tumors is associated with the development of
microregions of heterogeneous cells and environments. Experimental models such as …

An appropriate cellular response to implanted surfaces is essential for tissue regeneration
and integration. It is well described that implanted materials are immediately coated with …

Based on the existing literature, a model is presented that postulates a “dynamic reciprocity”
between the extracellular matrix (ECM) on the one hand and the cytoskeleton and the …

▪ Abstract Focal adhesions are sites of tight adhesion to the underlying extracellular matrix
developed by cells in culture. They provide a structural link between the actin cytoskeleton …

The differentiation and growth of adult stem cells within engineered tissue constructs are
hypothesized to be influenced by cell-biomaterial interactions. In this study, we compared …

Since the discovery of induced pluripotent stem cells (iPSCs), numerous approaches have
been explored to improve the original protocol, which is based on a two-dimensional (2D) …

The major challenge in biology today is biocomplexity: the need to explain how cell and
tissue behaviors emerge from collective interactions within complex molecular networks …