Proteases are signaling molecules that specifically control cellular functions by cleaving
protease-activated receptors (PARs). The four known PARs are members of the large family …

Inflammatory diseases have become increasingly prevalent with industrialization. To
address this, numerous anti-inflammatory agents and molecular targets have been …

Kallikrein-related peptidases (KLKs) are critical regulators of the tumour microenvironment.
KLKs are proteolytic enzymes regulating multiple functions of bioactive molecules including …

Rosacea is a common chronic inflammatory skin disease of the central facial skin and is of
unknown origin. Currently, two classifications of rosacea exist that are based on either …

Netherton syndrome (NS) is a severe genetic skin disease with constant atopic
manifestations that is caused by mutations in the serine protease inhibitor Kazal-type 5 …

In addition to their role in protein degradation and digestion, proteases can also function as
hormone-like signaling molecules that regulate vital patho-physiological processes …

Abstract Proteinase-activated receptors (PARs), a family of four seven-transmembrane G
protein-coupled receptors, act as targets for signalling by various proteolytic enzymes. PARs …

Protease-activated receptors (PARs) are G protein-coupled receptors that are activated by
proteolytical cleavage of the amino-terminus and thereby act as sensors for extracellular …

Proteinase‐activated receptors (PARs) are a four‐member family of G protein‐coupled
receptors defined by their irreversible proteolytic mechanism of activation. PARs have …

The 15 members of the kallikrein-related serine peptidase (KLK) family have diverse tissue-
specific expression profiles and putative proteolytic functions. The kallikrein family is also …