The application of omics-based human liver platforms for investigating the mechanism of drug-induced hepatotoxicity in vitro
Drug-induced liver injury (DILI) complicates safety assessment for new drugs and poses
major threats to both patient health and drug development in the pharmaceutical industry. A …
major threats to both patient health and drug development in the pharmaceutical industry. A …
[HTML][HTML] Identification of a functional antioxidant response element at the HIF1A locus
Reactive oxygen species (ROS), which are a byproduct of oxidative metabolism, serve as
signaling molecules in a number of physiological settings. However, if their levels are not …
signaling molecules in a number of physiological settings. However, if their levels are not …
ROS networks: designs, aging, Parkinson's disease and precision therapies
How the network around ROS protects against oxidative stress and Parkinson's disease
(PD), and how processes at the minutes timescale cause disease and aging after decades …
(PD), and how processes at the minutes timescale cause disease and aging after decades …
AOP report: development of an adverse outcome pathway for oxidative DNA damage leading to mutations and chromosomal aberrations
E Cho, A Allemang, M Audebert… - Environmental and …, 2022 - Wiley Online Library
Abstract The Genetic Toxicology Technical Committee (GTTC) of the Health and
Environmental Sciences Institute (HESI) is developing adverse outcome pathways (AOPs) …
Environmental Sciences Institute (HESI) is developing adverse outcome pathways (AOPs) …
N‐acetyl‐serotonin protects HepG2 cells from oxidative stress injury induced by hydrogen peroxide
J Jiang, S Yu, Z Jiang, C Liang, W Yu… - Oxidative Medicine …, 2014 - Wiley Online Library
Oxidative stress plays an important role in the pathogenesis of liver diseases. N‐Acetyl‐
serotonin (NAS) has been reported to protect against oxidative damage, though the …
serotonin (NAS) has been reported to protect against oxidative damage, though the …
Inhibitory Effect of Delphinidin on Oxidative Stress Induced by H2O2 in HepG2 Cells
J Xu, Y Zhang, G Ren, R Yang, J Chen… - Oxidative Medicine …, 2020 - Wiley Online Library
Chronic liver diseases (CLDs) are correlated with oxidative stress induced by the
accumulation of intracellular reactive oxygen species (ROS). In this study, we employed …
accumulation of intracellular reactive oxygen species (ROS). In this study, we employed …
[HTML][HTML] Monitoring structural modulation of redox-sensitive proteins in cells with MS-CETSA
Reactive oxygen species (ROS) induce different cellular stress responses but can also
mediate cellular signaling. Augmented levels of ROS are associated with aging, cancer as …
mediate cellular signaling. Augmented levels of ROS are associated with aging, cancer as …
Capturing time-dependent activation of genes and stress-response pathways using transcriptomics in iPSC-derived renal proximal tubule cells
P Jennings, G Carta, P Singh… - Cell biology and …, 2023 - Springer
Transcriptomic analysis is a powerful method in the utilization of New Approach Methods
(NAMs) for identifying mechanisms of toxicity and application to hazard characterization …
(NAMs) for identifying mechanisms of toxicity and application to hazard characterization …
Transcriptome analysis of human OXR1 depleted cells reveals its role in regulating the p53 signaling pathway
The oxidation resistance gene 1 (OXR1) is crucial for protecting against oxidative stress;
however, its molecular function is unknown. We employed RNA sequencing to examine the …
however, its molecular function is unknown. We employed RNA sequencing to examine the …
Antioxidant activity of chia flour as a food supplement in a cellular model: Repercussions of processing and in vitro digestion
AL Mas, ME Sabatino, MG Theumer, DA Wunderlin… - Heliyon, 2024 - cell.com
Food processing and digestion can alter bioactive compound composition of food, affecting
their potential biological activity. In this study, we evaluated the direct and protective …
their potential biological activity. In this study, we evaluated the direct and protective …