Cardiovascular disease (CVD) presents a great burden for elderly patients, their caregivers,
and health systems. Structural and functional alterations of vessels accumulate throughout …

Ageing is the main risk factor for the development of cardiovascular diseases. A central
mechanism by which ageing promotes vascular pathologies is compromising endothelial …

Cellular senescence, a major tumor-suppressive cell fate, has emerged from humble
beginnings as an in vitro phenomenon into recognition as a fundamental mechanism of …

INTRODUCTION: It is well established that type 1 diabetes (T1D) is an autoimmune disease.
Controversial data exists regarding the differential control of the immune system in T1D …

The age-related loss of skeletal muscle mass and function that is associated with sarcopenia
can result in ultimate consequences such as decreased quality of life. The causes of …

Age is a significant risk factor for the development of vascular diseases, such as
atherosclerosis. Although pharmacological treatments, including statins and anti …

Aging is marked by changes that affect organs and resident stem cell function. Shorting of
telomeres, DNA damage, oxidative stress, deregulation of genes and proteins, impaired cell …

Over the past 66 years, our knowledge of the role of the endothelium in the regulation of
cardiovascular function and dysfunction has advanced from the assumption that it is a single …

Circulating bone-marrow-derived cells, named endothelial progenitor cells (EPCs), are
capable of maintaining, generating, and replacing terminally differentiated cells within their …

Objectives: The purpose of this study was to determine the role of circulating endothelial
progenitor cells with osteoblastic phenotype (EPC-OCN) in human aortic valve calcification …