Applications and advancements of nanoparticle-based drug delivery in alleviating lung cancer and chronic obstructive pulmonary disease

G De Rubis, KR Paudel, L Corrie, S Mehndiratta… - Naunyn-Schmiedeberg's …, 2024 - Springer
Lung cancer (LC) and chronic obstructive pulmonary disease (COPD) are among the
leading causes of mortality worldwide. Cigarette smoking is among the main aetiologic …

Bispecific antibodies in lung cancer: a state-of-the-art review

AA Khosla, K Jatwani, R Singh, A Reddy, I Jaiyesimi… - Pharmaceuticals, 2023 - mdpi.com
Bispecific antibodies have emerged as a promising class of therapeutics in the field of
oncology, offering an innovative approach to target cancer cells while sparing healthy …

LncRNA-HOXC-AS2 regulates tumor-associated macrophage polarization through the STAT1/SOCS1 and STAT1/CIITA pathways to promote the progression of non …

C Yin, J Li, S Li, X Yang, Y Lu, C Wang, B Liu - Cellular Signalling, 2024 - Elsevier
Tumor-associated macrophages (TAMs) mainly exhibit the characteristics of M2-type
macrophages, and the regulation of TAM polarization is a new target for cancer therapy …

Ribavirin attenuates carcinogenesis by downregulating IL-6 and IL-8 in vitro in human lung adenocarcinoma

G De Rubis, KR Paudel, S Yeung, V Agarwal… - … -Research and Practice, 2024 - Elsevier
Lung cancer is one of the leading causes of death worldwide, whereby the major
contributing factors are cigarette smoking and exposure to environmental pollutants. Despite …

The Interplay Between HIF‐1α and EZH2 in Lung Cancer and Dual‐Targeted Drug Therapy

J Wang, C Yang, H Xu, X Fan, L Jia, Y Du… - Advanced …, 2024 - Wiley Online Library
Interactions between oncogenic proteins contribute to the phenotype and drug resistance.
Here, EZH2 (enhancer of zest homolog 2) is identified as a crucial factor that mediates HIF‐1 …

Nano-formulations for pulmonary delivery: Past, present, and future perspectives

S Peng, W Wang, R Zhang, C Wu, X Pan, Z Huang - Pharmaceutics, 2024 - mdpi.com
With the development of nanotechnology and confronting the problems of traditional
pharmaceutical formulations in treating lung diseases, inhalable nano-formulations have …

Integrated network pharmacology, molecular docking, molecular simulation, and in vitro validation revealed the bioactive components in soy-fermented food products …

AEO Elkhalifa, H Banu, MI Khan, SA Ashraf - Nutrients, 2023 - mdpi.com
Globally, lung cancer remains one of the leading causes of cancer-related mortality,
warranting the exploration of novel and effective therapeutic approaches. Soy-fermented …

Determination of Antioxidant, Cytotoxicity, and Anti-human Lung Cancer Properties of Silver Nanoparticles Green-Formulated by Foeniculum vulgare Extract …

Q Wu, Z Qin, P Sun, F Liu, Y Ge, P Wang - Biological Trace Element …, 2024 - Springer
The current investigation involved the silver nanoparticles green synthesis utilizing the
aqueous extract derived from the Foeniculum vulgare leaves (AgNPs@ FV). The …

lncRNAs as prognostic markers and therapeutic targets in cuproptosis-mediated cancer

AA Bhat, M Afzal, E Moglad, R Thapa, H Ali… - Clinical and …, 2024 - Springer
Long non-coding RNAs (lncRNAs) have emerged as crucial regulators in various cellular
processes, including cancer progression and stress response. Recent studies have …

Daidzein nanosuspension in combination with cisplatin to enhance therapeutic efficacy against A549 non-small lung cancer cells: an in vitro evaluation

S Oncu, M Becit-Kizilkaya, S Sen… - Naunyn-Schmiedeberg's …, 2024 - Springer
Lung cancer is the most common cause of cancer-related mortality, chemo-resistance, and
toxicity limit treatment. The focus is on innovative combined phytotherapy to improve …