Overview of physiological, biochemical, and regulatory aspects of nitrogen fixation in Azotobacter vinelandii
JS Martin del Campo, J Rigsbee… - Critical Reviews in …, 2022 - Taylor & Francis
Understanding how Nature accomplishes the reduction of inert nitrogen gas to form
metabolically tractable ammonia at ambient temperature and pressure has challenged …
metabolically tractable ammonia at ambient temperature and pressure has challenged …
The interactions of molecular chaperones with client proteins: why are they so weak?
T Arhar, A Shkedi, CM Nadel, JE Gestwicki - Journal of Biological Chemistry, 2021 - ASBMB
The major classes of molecular chaperones have highly variable sequences, sizes, and
shapes, yet they all bind to unfolded proteins, limit their aggregation, and assist in their …
shapes, yet they all bind to unfolded proteins, limit their aggregation, and assist in their …
Molecular mechanism of ISC iron–sulfur cluster biogenesis revealed by high-resolution native mass spectrometry
Iron–sulfur (Fe–S) clusters are ubiquitous protein cofactors that are required for many
important biological processes including oxidative respiration, nitrogen fixation, and …
important biological processes including oxidative respiration, nitrogen fixation, and …
Native mass spectrometric studies of IscSU reveal a concerted, sulfur-initiated mechanism of iron–sulfur cluster assembly
SP Bennett, JC Crack, R Puglisi, A Pastore… - Chemical …, 2023 - pubs.rsc.org
Iron–sulfur (Fe–S) clusters are cofactors essential for life. Though the proteins that function
in the assembly of Fe–S clusters are well known, details of the molecular mechanism are …
in the assembly of Fe–S clusters are well known, details of the molecular mechanism are …
[HTML][HTML] Metamorphic protein IscU alternates conformations in the course of its role as the scaffold protein for iron–sulfur cluster biosynthesis and delivery
IscU from Escherichia coli, the scaffold protein for iron-sulfur cluster biosynthesis and
delivery, populates a complex energy landscape. IscU exists as two slowly interconverting …
delivery, populates a complex energy landscape. IscU exists as two slowly interconverting …
Interaction of client—the scaffold on which FeS clusters are build—with J-domain protein Hsc20 and its evolving Hsp70 partners
J Marszalek, EA Craig - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
In cells molecular chaperone systems consisting of Hsp70 and its obligatory J-domain
protein (JDP) co-chaperones transiently interact with a myriad of client proteins—with JDPs …
protein (JDP) co-chaperones transiently interact with a myriad of client proteins—with JDPs …
Chaperone function in Fe–S protein biogenesis: Three possible scenarios.
Among the six known iron‑sulfur (Fesingle bondS) cluster biogenesis machineries that
function across all domains of life only one involves a molecular chaperone system. This …
function across all domains of life only one involves a molecular chaperone system. This …
Mechanism of mitochondrial [2Fe2S] cluster biosynthesis
K Want, B D'Autréaux - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2024 - Elsevier
Iron‑sulfur (Fesingle bondS) clusters constitute ancient cofactors that accompany a versatile
range of fundamental biological reactions across eukaryotes and prokaryotes. Several …
range of fundamental biological reactions across eukaryotes and prokaryotes. Several …
Role of IscX in Iron–Sulfur Cluster Biogenesis in Escherichia coli
The Escherichia coli isc operon encodes key proteins involved in the biosynthesis of iron–
sulfur (Fe–S) clusters. Whereas extensive studies of most ISC proteins have revealed their …
sulfur (Fe–S) clusters. Whereas extensive studies of most ISC proteins have revealed their …
Human mitochondrial chaperone (mtHSP70) and cysteine desulfurase (NFS1) bind preferentially to the disordered conformation, whereas co-chaperone (HSC20) …
Background: Iron-sulfur cluster biosynthesis involves a scaffold protein (ISCU), cysteine
desulfurase (NFS1), chaperone (mtHSP70), and co-chaperone (HSC20). Results: Human …
desulfurase (NFS1), chaperone (mtHSP70), and co-chaperone (HSC20). Results: Human …