Repair and reconstruction of critical-size bone defects have been challenges in the clinic for
many years. Stem cell therapy is a promising strategy for these dilemmas, and induced …

The clinical translation of mesenchymal stem cells (MSCs) is limited by population
heterogeneity and inconsistent responses to engineered signals. Specifically, the extent in …

Calcium phosphate cements (CPCs) have been widely used for the study of bone
regeneration because of their excellent physical and chemical properties, but poor …

Background Human mesenchymal stem cells are a strong candidate for cell therapies owing
to their regenerative potential, paracrine regulatory effects, and immunomodulatory activity …

Bone engineering makes it possible to grow unlimited amounts of viable tissue products for
basic and applied research, and for clinical applications. A common trend in tissue …

Decellularized extracellular matrix (dECM) hydrogels are engineered constructs that are
widely-used in the field of regenerative medicine. However, the development of ECM-based …

A novel way of obtaining highly porous cements is foaming them with the use of nonionic
surface active agents (surfactants). In this study, foamed calcium phosphate cements …

A three-dimensional porous hydroxyapatite nanocomposite has been synthesized by a
simple, less energy consuming and cost effective one-pot method. In this study, gelatin foam …

To foster translation and commercialization of tissue‐engineered products, preservation
methods that do not significantly compromise tissue properties need to be designed and …

Melatonin (MT) has been served as promising osteogenic factor to promote osteogenesis.
However, the direct injection of MT is accompanied by its fast diffusion and rapid …