Cisplatin is a widely used chemotherapeutic agent used to treat solid tumours, such as
ovarian, head and neck, and testicular germ cell. A known complication of cisplatin …

Acute kidney injury (AKI) following platinum-based chemotherapeutics is a frequently
reported serious side-effect. However, there are no approved biomarkers that can properly …

The nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) cell signaling
pathway is important in inflammation and cell survival. Inflammation and cell death in the …

Purpose Acute kidney injury (AKI) is a common and serious adverse effect of cisplatin-based
chemotherapy. However, traditional markers of kidney function, such as serum creatinine …

Acute kidney injury (AKI) is a severe and frequent condition in hospitalized patients.
Currently, no efficient therapy of AKI is available. Therefore, efforts focus on early prevention …

Despite recent progress in the development of novel approaches to treat cancer, traditional
antineoplastic drugs, such as cisplatin, remain a mainstay of regimens targeting solid …

C57BL/6 mice are one of the most commonly used mouse strains in research, especially in
kidney injury studies. However, C57BL/6 mice are resistant to chronic kidney disease …

Several biomarkers are used to monitor organ damage caused by drug toxicity. Traditional
markers of kidney function, such as serum creatinine and blood urea nitrogen are commonly …

Phenylthiobutanoic acids (PTBAs) are a new class of histone deacetylase (HDAC) inhibitors
that accelerate recovery and reduce postinjury fibrosis after ischemia-reperfusion-induced …

As a common anticancer drug, cisplatin has been widely used for treating tumors in the
clinic. However, its side effects, especially its nephrotoxicity, noticeably restrict the …