With the rising application of systems biology, sensitivity analysis methods have been widely
applied to study the biological systems, including metabolic networks, signalling pathways …

Vaccination is still the most successful strategy to prevent and control the spread of
infectious diseases by generating an adequate protective immune response. However …

Sepsis represents a dysregulated host response to infection, the extent of which determines
the severity of organ dysfunction and subsequent outcome. All trialled immunomodulatory …

Background Biochemical reaction networks are self‐regulated in part due to feedback
activation mechanisms. The tissue factor (TF) pathway of blood coagulation is a complex …

For nearly five decades since its discovery, the role of natural IgG, which pre‐exists in
neonates and uninfected individuals, has remained unclear due to the general perception …

Systems biology is in an exponential development stage in recent years and has been
widely utilized in biomedicine to better understand the molecular basis of human disease …

The complement system is an integral part of innate immunity that detects and eliminates
invading pathogens through a cascade of reactions. The destructive effects of the …

Toll-like receptors (TLRs) recognize pathogen-associated molecular patterns (PAMPs) and
stimulate the innate immune response through the production of cytokines. The innate …

An innate immune cell can sense a pathogen, either from a distance by recognizing
chemoattractant stimuli or by direct physical contact. The pathogen is subsequently …

Cancer is a complex, multifaceted disease. Cellular systems are perturbed both during the
onset and development of cancer, and the behavioural change of tumour cells usually …