Increasing evidence supports a critical role for the eosinophil in disease. Here, the
mechanisms underlying eosinophil-associated inflammation are reviewed including …

Eosinophil granulocytes are intriguing members of the innate immunity system that have
been considered important defenders during parasitic diseases as well as culprits during …

Allergic asthma is characterized by airway hyperresponsiveness and pulmonary
eosinophilia, and may be mediated by T helper (Th) lymphocytes expressing a Th2 cytokine …

Asthma is an inflammatory disease of the airways that is induced by Th2 cytokines and
inhibited by Th1 cytokines. Despite a steady increase in the incidence, morbidity, and …

We have examined the effects of direct intratracheal instillation of purified eosinophil granule
proteins on pulmonary function and airway responsiveness in primates. The results of this …

Airway inflammation and airway hyperresponsiveness (AHR) are hallmarks of asthma.
Cytokines produced by T helper type 2 (Th2) lymphocytes have been implicated in both …

Segmental entlgen bronchoprovocatlon was used to define the nature of the Inflammatory
process In allergic airway disease. Bronchoalveolar lavage fluid obtained from allergic …

Inflammation of the airway wall and airway hyperresponslveness are consistent features of
chronic asthma. We investigated how damage of the bronchial epithelium Is related to …

Eosinophils and T lymphocytes are thought to be involved in allergic airway inflammation.
Both cells express the alpha 4 beta 1-integrin, very late antigen-4 (VLA-4, CD49d/CD29); …

Mucosal eosinophils increase in a number of gastrointestinal diseases that are often
associated with altered epithelial barrier function, including food allergic enteropathies and …