The aminoacyl-tRNA synthetases are an essential and universally distributed family of
enzymes that plays a critical role in protein synthesis, pairing tRNAs with their cognate …

Translating the 4-letter code of RNA into the 22-letter alphabet of proteins is a central feature
of cellular life. The fidelity with which mRNA is translated during protein synthesis is …

The aminoacyl‐tRNA synthetases are prominently known for their classic function in the first
step of protein synthesis, where they bear the responsibility of setting the genetic code. Each …

Aminoacyl-tRNA synthetases (aaRS) ensure the faithful transmission of genetic information
in all living cells. The 24 known aaRS families are divided into 2 structurally distinct classes …

Genetic code expansion for synthesis of proteins containing noncanonical amino acids is a
rapidly growing field in synthetic biology. Creating optimal orthogonal translation systems …

Abstract Mitochondrial (mt‐) tRNA (MTT) gene mutations are an important cause of human
morbidity and are associated with a wide range of pathology, from isolated organ‐specific …

Mistranslation broadly encompasses the introduction of errors during any step of protein
synthesis, leading to the incorporation of an amino acid that is different from the one …

Accurate translation of mRNA into protein is vital for maintenance of cellular integrity.
Translational fidelity is achieved by two key events: synthesis of correctly paired aminoacyl …

Genetic efficiency in higher organisms depends on mechanisms to create multiple functions
from single genes. To investigate this question for an enzyme family, we chose aminoacyl …

Mycoplasma parasites escape host immune responses via mechanisms that depend on
remarkable phenotypic plasticity. Identification of these mechanisms is of great current …