The genetically encoded fluorescent sensors convert chemical and physical signals into
light. They are powerful tools for the visualisation of physiological processes in living cells …

Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

Zinc is involved in a variety of biological processes, as a structural, catalytic, and intracellular
and intercellular signaling component. Thus zinc homeostasis is tightly controlled at the …

All life forms have an absolute requirement for metals, as metals play critical roles in
fundamental processes, including osmotic regulation, catalysis, metabolism …

Vitamin B 12, cobalamin, is a cobalt-containing ring-contracted modified tetrapyrrole that
represents one of the most complex small molecules made by nature. In prokaryotes it is …

Almost half of all enzymes must associate with a particular metal to function. An ambition is
to understand why each metal–protein partnership arose and how it is maintained. Metal …

Our knowledge of the molecular mechanisms of intracellular homeostatic control of zinc ions
is now firmly grounded on experimental findings gleaned from the study of zinc proteomes …

Essential metal ions are tightly controlled in biological systems. An understanding of metal
metabolism and homeostasis is being developed from quantitative information of the sizes …

We developed genetically encoded fluorescence resonance energy transfer (FRET)-based
sensors that display a large ratiometric change upon Zn2+ binding, have affinities that span …

In the past 5–10 years, the power of the green fluorescent protein (GFP) and its numerous
derivatives has been harnessed toward the development of genetically encoded fluorescent …