The pathology of chronic obstructive pulmonary disease
The pathogenesis of chronic obstructive pulmonary disease (COPD) is based on the innate
and adaptive inflammatory immune response to the inhalation of toxic particles and gases …
and adaptive inflammatory immune response to the inhalation of toxic particles and gases …
Toll-like receptors in inflammation, infection and cancer
Members of the Toll-like receptor (TLR) family play key roles in both innate and adaptive
immune responses. TLR proteins enable host to recognize a large number of pathogen …
immune responses. TLR proteins enable host to recognize a large number of pathogen …
TLRs in pulmonary diseases
Toll-like receptors (TLRs) comprise a clan of proteins involved in identification and triggering
a suitable response against pathogenic attacks. As lung is steadily exposed to multiple …
a suitable response against pathogenic attacks. As lung is steadily exposed to multiple …
What Can We Learn About Human Disease from the Nematode C. elegans?
J Apfeld, S Alper - Disease Gene Identification: Methods and Protocols, 2018 - Springer
Numerous approaches have been taken in the hunt for human disease genes. The
identification of such genes not only provides a great deal of information about the …
identification of such genes not only provides a great deal of information about the …
Translational mini-review series on Toll-like receptors: networks regulated by Toll-like receptors mediate innate and adaptive immunity
The Toll-like receptor (TLR) family provide key components of mammalian immunity and are
part of the earliest surveillance mechanisms responding to infection. Their activation triggers …
part of the earliest surveillance mechanisms responding to infection. Their activation triggers …
Dual role of Toll-like receptors in asthma and chronic obstructive pulmonary disease
GFG Bezemer, S Sagar… - Pharmacological …, 2012 - Elsevier
During the last decade, significant research has been focused on Toll-like receptors (TLRs)
in the pathogenesis of airway diseases. TLRs are pattern recognition receptors that play …
in the pathogenesis of airway diseases. TLRs are pattern recognition receptors that play …
Toll-like receptor 2, 3, and 4 expression and function in human airway smooth muscle
MB Sukkar, S Xie, NM Khorasani, OM Kon… - Journal of Allergy and …, 2006 - Elsevier
BACKGROUND: Host defense against microbial pathogens is elicited through the innate
immune system by means of Toll-like receptors (TLRs). Airway smooth muscle cells …
immune system by means of Toll-like receptors (TLRs). Airway smooth muscle cells …
Lung epithelium as a sentinel and effector system in pneumonia–molecular mechanisms of pathogen recognition and signal transduction
Pneumonia, a common disease caused by a great diversity of infectious agents is
responsible for enormous morbidity and mortality worldwide. The bronchial and lung …
responsible for enormous morbidity and mortality worldwide. The bronchial and lung …
TLR7/9 antagonists as therapeutics for immune-mediated inflammatory disorders
L Karlsson, S Sun, NL Rao, J Venable… - … & Allergy-Drug …, 2007 - ingentaconnect.com
There is an increasing interest in ligands of nucleic acid-sensing Toll-like receptors (TLR),
especially TLR7 and TLR9, for pharmacological intervention in various diseases. The TLR7 …
especially TLR7 and TLR9, for pharmacological intervention in various diseases. The TLR7 …
The role of toll-like receptors in acute and chronic lung inflammation
EI Lafferty, ST Qureshi, M Schnare - Journal of Inflammation, 2010 - Springer
By virtue of its direct contact with the environment, the lung is constantly challenged by
infectious and non-infectious stimuli that necessitate a robust yet highly controlled host …
infectious and non-infectious stimuli that necessitate a robust yet highly controlled host …