The advent of chimeric antigen receptor (CAR) T cell therapy has resulted in unprecedented
long-term clearance of relapse/refractory hematological malignancies in both pediatric and …

As an emerging sequencing technology, single-cell RNA sequencing (scRNA-Seq) has
become a powerful tool for describing cell subpopulation classification and cell …

Regulatory T (Treg) cells are essential for maintaining peripheral tolerance, preventing
autoimmunity, and limiting chronic inflammatory diseases. This small CD4+ T cell population …

Caused by the loss in the tolerance against self‐antigens, autoimmune diseases are chronic
disorders that impact millions of individuals annually with significant economic burden. They …

Critical insights into the etiology of type 1 diabetes (T1D) came from genome-wide
association studies that unequivocally connected genetic susceptibility to immune cell …

Modern industrial practices have transformed the human diet over the last century,
increasing the consumption of processed foods. Dietary imbalance of macro-and micro …

Human umbilical cord blood (CB) and umbilical cord tissue (UC) are attractive sources of
somatic stem cells for gene and cell therapies. CB and UC can be obtained noninvasively …

Regulatory T cells (Tregs) are a subtype of CD4+ T cells that can mediate immune tolerance
by a multitude of immunomodulatory mechanisms. Treg-based adoptive immunotherapy is …

Decidual regulatory T cells (Tregs) are essential for successful pregnancy outcome. A
subset of Tregs, T cell immunoglobulin and mucin domain-containing protein 3–positive …

CD4+ CD25hiCD127lo/− FOXP3+ regulatory T cells (Tregs) play a key role in preventing
autoimmunity. In autoimmune type 1 diabetes (T1D), adoptive transfer of autologous …