[HTML][HTML] Helicobacter pylori in human health and disease: Mechanisms for local gastric and systemic effects

D Bravo, A Hoare, C Soto, MA Valenzuela… - World journal of …, 2018 - ncbi.nlm.nih.gov
Helicobacter pylori (H. pylori) is present in roughly 50% of the human population worldwide
and infection levels reach over 70% in developing countries. The infection has classically …

The human gastric microbiota: Is it time to rethink the pathogenesis of stomach diseases?

G Nardone, D Compare - United European gastroenterology …, 2015 - journals.sagepub.com
Introduction Although long thought to be a sterile organ, due to its acid production, the
human stomach holds a core microbiome. Aim To provide an update of findings related to …

The gastric microbiome, its interaction with Helicobacter pylori, and its potential role in the progression to stomach cancer

JM Noto, RM Peek Jr - PLoS pathogens, 2017 - journals.plos.org
Gastric adenocarcinoma is the third leading cause of cancer-related death worldwide,
accounting for more than 720,000 deaths annually [1]. The strongest known risk factor for …

Gastrointestinal malignancy and the microbiome

MT Abreu, RM Peek Jr - Gastroenterology, 2014 - Elsevier
Microbial species participate in the genesis of a substantial number of malignancies—in
conservative estimates, at least 15% of all cancer cases are attributable to infectious agents …

The interaction between smoking, alcohol and the gut microbiome

G Capurso, E Lahner - Best practice & research Clinical gastroenterology, 2017 - Elsevier
The gastrointestinal microbiome is a complex echosystem that establishes a symbiotic,
mutually beneficial relation with the host, being rather stable in health, but affected by age …

Gastric colonisation with a restricted commensal microbiota replicates the promotion of neoplastic lesions by diverse intestinal microbiota in the Helicobacter pylori …

K Lertpiriyapong, MT Whary, S Muthupalani, JL Lofgren… - Gut, 2014 - gut.bmj.com
Objectives Gastric colonisation with intestinal flora (IF) has been shown to promote
Helicobacter pylori (Hp)-associated gastric cancer. However, it is unknown if the mechanism …

Helicobacter pylori activates and expands Lgr5+ stem cells through direct colonization of the gastric glands

M Sigal, ME Rothenberg, CY Logan, JY Lee… - Gastroenterology, 2015 - Elsevier
Background & Aims Helicobacter pylori infection is the main risk factor for gastric cancer. We
characterized the interactions of H pylori with gastric epithelial progenitor and stem cells in …

The role of the gastrointestinal microbiome in Helicobacter pylori pathogenesis

A Sheh, JG Fox - Gut microbes, 2013 - Taylor & Francis
The discovery of Helicobacter pylori overturned the conventional dogma that the stomach
was a sterile organ and that pH values< 4 were capable of sterilizing the stomach. H. pylori …

The gastric and intestinal microbiome: role of proton pump inhibitors

A Minalyan, L Gabrielyan, D Scott, J Jacobs… - Current …, 2017 - Springer
Purpose of review The discovery of Helicobacter pylori and other organisms colonizing the
stomach and the intestines has shed some light on the importance of microbiome in …

Survival in hostile territory: the microbiota of the stomach

I Yang, S Nell, S Suerbaum - FEMS microbiology reviews, 2013 - academic.oup.com
The human stomach is a formidable barrier to orally ingested microorganisms and was long
thought to be sterile. The discovery of Helicobacter pylori, a carcinogenic bacterial pathogen …