The mammalian genome encodes 28 distinct members of the transient receptor potential
(TRP) superfamily of cation channels, which exhibit varying degrees of selectivity for …

Abstract The TRP (Transient Receptor Potential) superfamily of cation channels is
remarkable in that it displays greater diversity in activation mechanisms and selectivities …

The heart responds to injury and chronic pressure overload by pathologic growth and
remodeling, which frequently result in heart failure and sudden death. Calcium-dependent …

The TRP family of ion channels transduce an extensive range of chemical and physical
signals. TRPC6 is a receptor-activated nonselective cation channel expressed widely in …

Calcium signals, pivotal in controlling cell function, can be generated by calcium entry
channels activated by plasma membrane depolarization or depletion of internal calcium …

Angiotensin (Ang) II participates in the pathogenesis of heart failure through induction of
cardiac hypertrophy. Ang II‐induced hypertrophic growth of cardiomyocytes is mediated by …

Sustained elevation in the intracellular Ca2+ concentration via Ca2+ influx, which is
activated by a variety of mechanisms, plays a central regulatory role for cardiovascular …

Regional alveolar hypoxia causes local vasoconstriction in the lung, shifting blood flow from
hypoxic to normoxic areas, thereby maintaining gas exchange. This mechanism is known as …

Abstract Calcium (Ca 2+) is a highly versatile second messenger that controls vascular
smooth muscle cell (VSMC) contraction, proliferation, and migration. By means of Ca 2+ …

Peter J. Calcraft1, Abdelilah Arredouani2, Zui Pan3, Xiaotong Cheng2, Jisen Tang4,
Margarida Ruas2, Katja Rietdorf2, Peihui Lin3, John Parrington2, Jianjie Ma3, A. Mark …