Highlights•A rational optimization of Streptomyces strains is possible.•This can be achieved
through rewiring of primary metabolism and regulatory networks.•Biosynthetic gene cluster …

Abstract Beta-glucosidase (EC 3.2. 1.21) catalyzes the hydrolysis of cellobiose and
cellooligosaccharides containing (1→ 4)-beta-glycosidic bonds to glucose, which is crucial …

Endophytes, being the co-evolution partners of green host plants, are factories of
pharmaceutically valuable novel natural products. Cochliobolus sp. APS1, an endophyte of …

The confluence of a large variety of factors, achievements and developments has resulted in
the current long-term success in graft transplants. Some of these events are reviewed …

An innovative and cost effective electrochemical sensor was fabricated to determine
tacrolimus (TAC) in pharmaceutical samples. In the present study, cobalt ferrite …

Background FK506, a macrolide mainly with immunosuppressive activity, can be produced
by various Streptomyces strains. However, one of the major challenges in the fermentation …

The US Department of Energy has listed levulinic acid (LA) as one of the top 12 compounds
derived from biomass. LA has gained much attention owing to its conversion into …

Recombinant human interferon-β (rhIFN-β) is therapeutically important and new
commercially viable approaches are needed for its increased production. In this study, a …

The bacterium Streptomyces sp. KN37 was isolated from the soil of Kanas, Xinjiang. The
broth dilution of strain KN37 has a strong inhibitory effect against a variety of crop …

In order to solve the problem of low and poor straw degradation in typical black soil areas of
Northeast China, the present study was carried out to screen the potential of in situ strains …