Image-based profiling is a maturing strategy by which the rich information present in
biological images is reduced to a multidimensional profile, a collection of extracted image …

Image-based cell profiling is a high-throughput strategy for the quantification of phenotypic
differences among a variety of cell populations. It paves the way to studying biological …

In morphological profiling, quantitative data are extracted from microscopy images of cells to
identify biologically relevant similarities and differences among samples based on these …

Natural products have been the main sources of new drugs. The different strategies have
been developed to find the new drugs based on natural products. The traditional and ethic …

Target-identification and mechanism-of-action studies have important roles in small-
molecule probe and drug discovery. Biological and technological advances have resulted in …

Image-based screening is used to measure a variety of phenotypes in cells and whole
organisms. Combined with perturbations such as RNA interference, small molecules, and …

Although drugs are intended to be selective, at least some bind to several physiological
targets, explaining side effects and efficacy. Because many drug–target combinations exist …

High-content screening (HCS), which combines automated fluorescence microscopy with
quantitative image analysis, allows the acquisition of unbiased multiparametric data at the …

Mutations in the tricarboxylic acid (TCA) cycle enzyme fumarate hydratase (FH) are
associated with a highly malignant form of renal cancer. We combined analytical chemistry …

Why do seemingly identical cells respond differently to a drug? To address this, we studied
the dynamics and variability of the protein response of human cancer cells to a …