Porcine-induced pluripotent stem cells (piPSCs) could serve as a great model system for
human stem cell preclinical research. However, the pluripotency gene network of piPSCs …

Single cell profiling techniques including multi-omics and spatial-omics technologies allow
researchers to study cell-cell variation within a cell population. These variations extend to …

Primordial germ cells (PGCs) arise from cells of the post-implantation epiblast in response to
cytokine signaling. PGC development can be recapitulated in vitro by differentiating epiblast …

Partial reprogramming by cyclic short-term expression of Yamanaka factors holds promise
for shifting cells to younger states and consequently delaying the onset of many diseases of …

IPSC-based disease modelling and pluripotency studies have sparked widespread
enthusiasm for more than 16 years of research. All this effort and knowledge have presented …

Characterization of pluripotent states, in which cells can both self-renew or differentiate, with
the irreversible loss of pluripotency, are important research areas in developmental biology …

Implantation is the hallmark event during early pregnancy where a connection between the
embryo and mother is formed. During the following phase of early postimplantation …

ABSTRACT A complete knockout (KO) of a single key pluripotency gene has been shown to
drastically affect embryonic stem cell (ESC) function and epigenetic reprogramming …