DNA tumor viruses such as simian virus 40 (SV40) express dominant acting oncoproteins
that exert their effects by associating with key cellular targets and altering the signaling …

DNA replication is a complicated process that is largely regulated during stages of initiation.
The Siman Virus 40 in vitro replication system has served as an excellent model for studies …

Merkel cell polyomavirus (MCV) is a virus discovered in our laboratory at the University of
Pittsburgh that is monoclonally integrated into the genome of≈ 80% of human Merkel cell …

We have examined the activation of the SV40 late promoter by inserting the late promoter
and the viral origin of replication into chloramphenicol acetyltransferase (CAT) transient …

The early simian virus 40 (SV40) gene product, large tumor (T) antigen, is responsible for
the initiation of viral DNA replication and the autoregulation of early gene expression …

Infection of a wide variety of rodent and human cells with simian virus 40 (SV40) will result in
the full phenotypic transformation of these cells and subsequent injection of such …

A cell‐free system for replication of SV40 DNA was used to assess the effect of mutations
altering either the SV40 origin of DNA replication or the virus‐encoded large tumor (T) …

The increasing frequency of tissue transplantation, recent progress in the development and
application of immunomodulators, and the depressingly high number of AIDS patients …

We have recently cloned a plasmid, pARS65, containing the sequences derived from mouse
liver DNA which can autonomously replicate in mouse and human cells (Ariga et al., 1987) …

We have combined in vitro DNA replication reactions and immunological techniques to
analyze biochemical interactions between simian virus (SV40) large T antigen and …