Network pharmacology prediction and molecular docking-based strategy to explore the potential mechanism of Huanglian Jiedu Decoction against sepsis

X Li, S Wei, S Niu, X Ma, H Li, M Jing, Y Zhao - Computers in biology and …, 2022 - Elsevier
Abstract Background Huanglian Jiedu Decoction (HLJDD) is a classical herbal formula with
potential efficacy in the treatment of sepsis. However, the main components and potential …

Mortality in sepsis and septic shock in Europe, North America and Australia between 2009 and 2019—results from a systematic review and meta-analysis

M Bauer, H Gerlach, T Vogelmann, F Preissing… - Critical Care, 2020 - Springer
Background Sepsis and septic shock remain drivers for mortality in critically ill patients. The
heterogeneity of the syndrome hinders the generation of reproducible numbers on mortality …

Guidelines on the Use of therapeutic apheresis in clinical practice–Evidence‐Based approach from the Writing Committee of the American Society for Apheresis: The …

L Connelly‐Smith, CR Alquist, NA Aqui… - Journal of clinical …, 2023 - Wiley Online Library
Abstract The American Society for Apheresis (ASFA) Journal of Clinical Apheresis (JCA)
Special Issue Writing Committee is charged with reviewing, updating, and categorizing …

[HTML][HTML] Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study

KE Rudd, SC Johnson, KM Agesa, KA Shackelford… - The Lancet, 2020 - thelancet.com
Background Sepsis is life-threatening organ dysfunction due to a dysregulated host
response to infection. It is considered a major cause of health loss, but data for the global …

Guidelines on the use of therapeutic apheresis in clinical practice–evidence‐based approach from the Writing Committee of the American Society for Apheresis: the …

A Padmanabhan, L Connelly‐Smith… - Journal of clinical …, 2019 - Wiley Online Library
ABSTRACT The American Society for Apheresis (ASFA) Journal of Clinical Apheresis (JCA)
Special Issue Writing Committee is charged with reviewing, updating and categorizing …

The pathogenesis of sepsis and potential therapeutic targets

M Huang, S Cai, J Su - International journal of molecular sciences, 2019 - mdpi.com
Sepsis is defined as “a life-threatening organ dysfunction caused by a host's dysfunctional
response to infection”. Although the treatment of sepsis has developed rapidly in the past …

The pathophysiology of sepsis and precision-medicine-based immunotherapy

EJ Giamarellos-Bourboulis, AC Aschenbrenner… - Nature …, 2024 - nature.com
Sepsis remains a major cause of morbidity and mortality in both low-and high-income
countries. Antibiotic therapy and supportive care have significantly improved survival …

The global burden of paediatric and neonatal sepsis: a systematic review

C Fleischmann-Struzek, DM Goldfarb… - The Lancet …, 2018 - thelancet.com
The incidence of sepsis is highest in neonates and children, yet the global burden of sepsis
in these age groups has not been assessed. We reviewed available evidence from …

Incidence and trends of sepsis in US hospitals using clinical vs claims data, 2009-2014

C Rhee, R Dantes, L Epstein, DJ Murphy, CW Seymour… - Jama, 2017 - jamanetwork.com
Importance Estimates from claims-based analyses suggest that the incidence of sepsis is
increasing and mortality rates from sepsis are decreasing. However, estimates from claims …

Time to treatment and mortality during mandated emergency care for sepsis

CW Seymour, F Gesten, HC Prescott… - … England Journal of …, 2017 - Mass Medical Soc
Background In 2013, New York began requiring hospitals to follow protocols for the early
identification and treatment of sepsis. However, there is controversy about whether more …