Fluorescent dyes based on rhodamine derivatives for bioimaging and therapeutics: recent progress, challenges, and prospects

S Zeng, X Liu, YS Kafuti, H Kim, J Wang… - Chemical Society …, 2023 - pubs.rsc.org
Since their inception, rhodamine dyes have been extensively applied in biotechnology as
fluorescent markers or for the detection of biomolecules owing to their good optical physical …

Population-level variation in enhancer expression identifies disease mechanisms in the human brain

P Dong, GE Hoffman, P Apontes, J Bendl, S Rahman… - Nature …, 2022 - nature.com
Identification of risk variants for neuropsychiatric diseases within enhancers underscores the
importance of understanding population-level variation in enhancer function in the human …

Safety, efficacy, and mechanisms of action of cannabinoids in neurological disorders

D Friedman, JA French, M Maccarrone - The Lancet Neurology, 2019 - thelancet.com
In the past two decades, there has been an increasing interest in the therapeutic potential of
cannabinoids for neurological disorders such as epilepsy, multiple sclerosis, pain, and …

[HTML][HTML] Monoacylglycerol lipase inhibitors: modulators for lipid metabolism in cancer malignancy, neurological and metabolic disorders

H Deng, W Li - Acta Pharmaceutica Sinica B, 2020 - Elsevier
Monoacylglycerol lipase (MAGL) is a serine hydrolase that plays a crucial role catalysing the
hydrolysis of monoglycerides into glycerol and fatty acids. It links the endocannabinoid and …

Major phytocannabinoids and their related compounds: should we only search for drugs that act on cannabinoid receptors?

LE Filipiuc, DC Ababei, T Alexa-Stratulat, CV Pricope… - Pharmaceutics, 2021 - mdpi.com
The most important discoveries in pharmacology, such as certain classes of analgesics or
chemotherapeutics, started from natural extracts which have been found to have effects in …

Peroxisome proliferator-activated receptor-γ ameliorates neuronal ferroptosis after traumatic brain injury in mice by inhibiting cyclooxygenase-2

H Liang, T Tang, H Huang, T Li, C Gao, Y Han… - Experimental …, 2022 - Elsevier
Among the multiple kinds of neuronal cell death triggered by traumatic brain injury (TBI),
ferroptosis, an iron-dependent lipid peroxidative regulatory cell death, has a critical role …

Cannabis-based products for the treatment of skin inflammatory diseases: A timely review

AM Martins, AL Gomes, I Vilas Boas, J Marto… - Pharmaceuticals, 2022 - mdpi.com
The use of natural products in dermatology is increasingly being pursued due to
sustainability and ecological issues, and as a possible way to improve the therapeutic …

Targeting endocannabinoid signaling: FAAH and MAG lipase inhibitors

N van Egmond, VM Straub… - Annual Review of …, 2021 - annualreviews.org
Inspired by the medicinal properties of the plant Cannabis sativa and its principal
component (−)-trans-Δ9-tetrahydrocannabinol (THC), researchers have developed a variety …

Inhibiting degradation of 2-arachidonoylglycerol as a therapeutic strategy for neurodegenerative diseases

C Chen - Pharmacology & therapeutics, 2023 - Elsevier
Endocannabinoids are endogenous lipid signaling mediators that participate in a variety of
physiological and pathological processes. 2-Arachidonoylglycerol (2-AG) is the most …

The role of n-3 PUFA-derived fatty acid derivatives and their oxygenated metabolites in the modulation of inflammation

I de Bus, R Witkamp, H Zuilhof, B Albada… - Prostaglandins & other …, 2019 - Elsevier
Notwithstanding the ongoing debate on their full potential in health and disease, there is
general consensus that n-3 PUFAs play important physiological roles. Increasing dietary n-3 …