Nicotinic acid and derivatives as multifunctional pharmacophores for medical applications

N Sinthupoom, V Prachayasittikul… - … Food Research and …, 2015 - Springer
Cardiovascular disease is one of the major health problems worldwide. It is a vascular
condition known as an atherosclerosis referring to the accumulation of immune cells and …

Antitumor activity of copper (I)–nicotinate complex and autophagy modulation in HCC1806 breast cancer cells

MA Abdel-Mohsen, CA Abdel Malak… - Anti-Cancer Agents …, 2017 - ingentaconnect.com
Background: Squamous cell cancer is a heterogeneous aggressive disease, therefore, its
treatment is challenging. Increased attention has been paid to metal complexes as …

A novel therapeutic drug (copper nicotinic acid complex) for non‐alcoholic fatty liver

RHM Salama, AYA Nassar, AAM Nafady… - Liver …, 2007 - Wiley Online Library
Background: Fatty liver is the accumulation of fat in liver cells, which leads to disruption of
the normal liver structure and function. Methods: A non‐alcoholic fatty liver rat model …

Mechanism of bioactive polysaccharide from Lachnum sp. acts synergistically with 5‐fluorouracil against human hepatocellular carcinoma

S Zong, J Li, L Yang, Q Huang, G Hou… - Journal of Cellular …, 2019 - Wiley Online Library
Abstract The antimetabolite 5‐fluorouracil (5‐FU) is a widely used antitumor agent, however
the overall response rate to 5‐FU as a single agent is usually limited. Herein, how Lachnum …

Time-dependent morphological and biochemical changes following cutaneous thermal burn injury and their modulation by copper nicotinate complex: an animal …

MAY Nassar, HMS Eldien, HSA Tawab… - Ultrastructural …, 2012 - Taylor & Francis
Background: Thermal tissue injury is partly mediated by reactive oxygen metabolites.
Oxygen free radicals are contributory to local tissue damage following thermal injury and …

Ameliorative effects of Copper (II) albumin complex against zinc oxide nanoparticles induced oxidative DNA damage in Sprague Dawley rats

AM Abdelnaem, H Fathy, D Yahia, MF Ali… - Toxicology and …, 2024 - Springer
Objective The present study was carried out to investigate the possible protective role of
copper (II) albumin against zinc oxide nanoparticles (ZnONPs) provoked DNA damage and …

[HTML][HTML] Evaluation of HCPTd1, d14-double passaged intervening chemotherapy protocol for hepatocellular carcinoma

ZJ Yu, JW Yu, W Cai, HX Yuan, XY Li… - World Journal of …, 2005 - ncbi.nlm.nih.gov
AIM: To establish a kind of standardization of the clinical chemotherapeutic prototypes for
unresectable hepatocellular carcinomas (HCC). METHODS: 10-Hydroxycamptothecin …

Protective effects of copper (I)-nicotinate complex against aflatoxicosis

AR Shatat, HMS Eldien, MY Nassar… - The Open …, 2013 - benthamopen.com
Aflatoxicosis mostly leads to serious clinical signs of malnutrition, growth retardation, and
impairment of utilization of nutrients, immunosupression, liver diseases and cancer …

Physiological studies on the effect of copper nicotinate (Cu–N complex) on the fish, Clarias gariepinus, exposed to mercuric chloride

MB Al-Salahy - Fish physiology and biochemistry, 2011 - Springer
Female catfish, Clarias gariepinus, were collected from the Nile River at Assiut region, were
divided into 7 groups. The first group was left as control, and the second was treated with …

Role of combined administration of COPPER-NICOTINIC acid complex and COENZYME Q10 against aluminium chloride–INDUCED oxidative stress in rat brain

SY Qusti, M Balgoon, ES Alzahrani… - …, 2018 - pharmacophorejournal.com
Alzheimer's disease (AD), is a series of chronic progressive mental deteriorations occurring
during or before the senile period characterized by progressive dementia as a result of brain …