Homeobox genes and the specification of neuronal identity

O Hobert - Nature Reviews Neuroscience, 2021 - nature.com
The enormous diversity of cell types that characterizes any animal nervous system is defined
by neuron-type-specific gene batteries that endow cells with distinct anatomical and …

Terminal selectors of neuronal identity

O Hobert - Current topics in developmental biology, 2016 - Elsevier
The analysis of the developmental programs that define many different neuron types in the
nematode Caenorhabditis elegans has revealed common themes in how distinct terminal …

A cellular and regulatory map of the cholinergic nervous system of C. elegans

L Pereira, P Kratsios, E Serrano-Saiz, H Sheftel… - Elife, 2015 - elifesciences.org
Nervous system maps are of critical importance for understanding how nervous systems
develop and function. We systematically map here all cholinergic neuron types in the male …

[HTML][HTML] Modular control of glutamatergic neuronal identity in C. elegans by distinct homeodomain proteins

E Serrano-Saiz, RJ Poole, T Felton, F Zhang… - Cell, 2013 - cell.com
The choice of using one of many possible neurotransmitter systems is a critical step in
defining the identity of an individual neuron type. We show here that the key defining feature …

A 4D single-cell protein atlas of transcription factors delineates spatiotemporal patterning during embryogenesis

X Ma, Z Zhao, L Xiao, W Xu, Y Kou, Y Zhang, G Wu… - Nature …, 2021 - nature.com
Complex biological processes such as embryogenesis require precise coordination of cell
differentiation programs across both space and time. Using protein-fusion fluorescent …

A cellular and regulatory map of the GABAergic nervous system of C. elegans

M Gendrel, EG Atlas, O Hobert - Elife, 2016 - elifesciences.org
Neurotransmitter maps are important complements to anatomical maps and represent an
invaluable resource to understand nervous system function and development. We report …

Differential expression of glutamate receptor subunits in the nervous system of Caenorhabditis elegans and their regulation by the homeodomain protein UNC-42

PJ Brockie, DM Madsen, Y Zheng… - Journal of …, 2001 - Soc Neuroscience
In almost all nervous systems, rapid excitatory synaptic communication is mediated by a
diversity of ionotropic glutamate receptors. In Caenorhabditis elegans, 10 putative ionotropic …

Dynamic regulation of axon guidance

TW Yu, CI Bargmann - Nature neuroscience, 2001 - nature.com
To reach their proper targets, axons rely upon the actions of highly conserved families of
attractive and repulsive guidance molecules, including the netrins, Slits, semaphorins and …

Plasticity of the electrical connectome of C. elegans

A Bhattacharya, U Aghayeva, EG Berghoff, O Hobert - Cell, 2019 - cell.com
The specific patterns and functional properties of electrical synapses of a nervous system
are defined by the neuron-specific complement of electrical synapse constituents. We …

A map of terminal regulators of neuronal identity in Caenorhabditis elegans

O Hobert - Wiley Interdisciplinary Reviews: Developmental …, 2016 - Wiley Online Library
Our present day understanding of nervous system development is an amalgam of insights
gained from studying different aspects and stages of nervous system development in a …