▪ Abstract V (D) J recombination is the specialized DNA rearrangement used by cells of the
immune system to assemble immunoglobulin and T-cell receptor genes from the preexisting …

Summary V (D) J recombination is the process by which antibody and T‐cell receptor
diversity is attained. During this process, antigen receptor gene segments are cleaved and …

Abstract The V (D) J recombination process insures the somatic diversification of
immunoglobulin and antigen T cell receptor encoding genes. This reaction is initiated by a …

A separate family of enzymes within the metallo‐β‐lactamase fold comprises several
important proteins acting on nucleic acid substrates, involved in DNA repair (Artemis, SNM1 …

Omenn syndrome (OS) is an inherited disorder characterized by an absence of circulating B
cells and an infiltration of the skin and the intestine by activated oligoclonal T lymphocytes …

Amorphic mutations in the recombination activating genes RAG1 and RAG2 have been
reported to cause T–B–SCID, whereas hypomorphic mutations led to the expansion of a few …

Mutations in recombination activating genes 1 and 2 (RAG1 and RAG2) cause a spectrum of
severe immunodeficiencies ranging from classical T cell–B cell–severe combined …

Combined immunodeficiencies with impaired numbers and function of T-and B-cells can be
attributed to defects in the recombinase activating genes (RAG). The products of these …

Abstract V (D) J recombination is the process that generates the diversity among T cell
receptors and is one of three mechanisms that contribute to the diversity of antibodies in the …

Three molecular mechanisms contribute to the diversity of the immune repertoire of B and T
cells: V (D) J recombination generates the primary repertoire in both cases, whereas class …