Acid-sensing ion channels (ASICs) are ligand-gated ion channels that are exquisitely
sensitive to extracellular protons and can sense transient as well as sustained acidification …

Background Acid-sensing ion channels (ASICs) are a group of amiloride-sensitive ligand-
gated ion channels belonging to the family of degenerin/epithelial sodium channels. ASICs …

Acid‐sensing ion channels (ASICs) are cationic channels activated by extracellular acidosis
that are expressed in both central and peripheral nervous systems. Although peripheral …

The adequate stimuli and molecular receptors for muscle metaboreceptors and nociceptors
are still under investigation. We used calcium imaging of cultured primary sensory dorsal …

Acid-sensing ion channel 3 (ASIC3) belongs to the epithelial sodium channel/degenerin
(ENaC/DEG) superfamily. There are 7 different ASIC subunits encoded by 5 different genes …

Background Inflammation-mediated hyperalgesia involves tissue acidosis and sensitization
of nociceptors. Many studies have reported increased expression of acid-sensing ion …

Advanced gene targeting technology and related tools in mice have been incorporated into
studies of acid-sensing ion channels (ASICs). A single ASIC subtype can be knocked out …

Release of substance P (SP) from nociceptive nerve fibers and activation of its receptor
neurokinin 1 (NK1) are important effectors in the transmission of pain signals. Nonetheless …

Background: Tissue acidosis is effective in causing chronic muscle pain. However, how
muscle nociceptors contribute to the transition from acute to chronic pain is largely unknown …

Sensing acidosis is an important somatosensory function in responses to ischemia,
inflammation, and metabolic alteration. Accumulating evidence has shown that acidosis is …