It's complicated… m6A-dependent regulation of gene expression in cancer

CM Fitzsimmons, PJ Batista - Biochimica et Biophysica Acta (BBA)-Gene …, 2019 - Elsevier
Cellular function relies on multiple pathways that are coordinated to ensure the proper
execution of gene expression networks. Failure to coordinate the multiple programs active in …

[HTML][HTML] New sights in cancer: Component and function of N6-methyladenosine modification

Y Hu, S Wang, J Liu, Y Huang, C Gong, J Liu… - Biomedicine & …, 2020 - Elsevier
M 6 A is the most prevalent modification among epigenetics. M 6 A occurs on different sites
of RNA and exerts important functions in specific circumstances, such as mRNA splicing …

Global trends in mortality from malignant mesothelioma: Analysis of WHO mortality database (1994‐2013)

O Abdel‐Rahman - The Clinical Respiratory Journal, 2018 - Wiley Online Library
Background and objective Little is known about the extent to which asbestos use ban has
affected global trends in malignant mesothelioma. This study investigated recent global …

The association of fat-mass-and obesity-associated gene polymorphism (rs9939609) with colorectal cancer: a case-control study

M Gholamalizadeh, ME Akbari, S Doaei… - Frontiers in …, 2021 - frontiersin.org
Background and Aim The association between the rs9939609 polymorphism of fat mass and
obesity-associated gene (FTO) and risk of colorectal cancer is controversial. This study aims …

Significant epitranscriptomes in heterogeneous cancer

M Konno, M Taniguchi, H Ishii - Cancer Science, 2019 - Wiley Online Library
Precision medicine places significant emphasis on techniques for the identification of DNA
mutations and gene expression by deep sequencing of gene panels to obtain medical data …

The effects of FTO gene rs9939609 polymorphism on the association between colorectal cancer and dietary intake

M Gholamalizadeh, M Jonoush, KA Mobarakeh… - Frontiers in …, 2023 - frontiersin.org
Background FTO gene is associated with obesity, dietary intake, and the risk of colorectal
cancer (CRC). In this study, patients with colorectal cancer were assessed for the …

RNA Modification Related Diseases and Sensing Methods

M Ohkawa, M Konno - Applied Sciences, 2023 - mdpi.com
Epitranscriptomics is the study of RNA base modifications, including functionally relevant
transcriptomic changes. Epitranscriptomics has been actively studied in recent years and …

Functions and mechanisms of N6‑methyladenosine in prostate cancer

H Wan, Y Feng, J Wu, L Zhu… - Molecular Medicine …, 2022 - spandidos-publications.com
Prostate cancer (PCa) has long been a major public health problem affecting men
worldwide. Even with treatment, it can develop into castration‑resistant PCa. With the …

Genetic polymorphisms in aquaporin 1 as risk factors for malignant mesothelioma and biomarkers of response to cisplatin treatment

B Senk, K Goricar, V Kovac, V Dolzan… - Radiology and …, 2019 - sciendo.com
Background. Malignant mesothelioma (MM) is an asbestos related aggressive tumor with
poor prognosis. The aim of this study was to investigate if aquaporin 1 (AQP1) genetic …

Epitranscriptomics and Diseases

M Konno, H Ishii - Epitranscriptomics, 2021 - Springer
The role of epitranscriptomics, ie, RNA base modification, as a component of a “methylome”
in disease has emerged as a result of the development of next generation sequencing and …