Cancer has become one of the greatest threats to human health, and new technologies are
urgently needed to further clarify the mechanisms of cancer so that better detection and …

Single-cell multi-omics technologies have revolutionized cancer research by allowing us to
examine individual cells at a molecular level. Unlike traditional bulk omics approaches …

Inferring cellular trajectories using a variety of omic data is a critical task in single-cell data
science. However, accurate prediction of cell fates, and thereby biologically meaningful …

Triple-negative breast cancer (TNBC) is a subtype of breast cancer with high intratumoral
heterogeneity. Recent studies revealed that TNBC patients might comprise cells with distinct …

Simple Summary Cells respond to genotoxic stress through complex protein pathways
called DNA damage response (DDR). These mechanisms ensure the preservation of …

DNA methylation is a highly regulated process that has a critical role in human development
and homeostatic control of the cell. The number of genes affected by anomalous DNA …

Background & Aims Colorectal cancer (CRC) is a devastating disease that is highly
modulated by dietary nutrients. Mechanistic target of rapamycin complex 1 (mTORC1) …

Single-cell RNA sequencing (scRNA-seq) massively profiles transcriptomes of individual
cells encapsulated in barcoded droplets in parallel. However, in real-world scRNA-seq data …

Despite the fact that 5-fluorouracil (5-FU) is the backbone for chemotherapy in colorectal
cancer (CRC), the response rates in patients is limited to 50%. The mechanisms underlying …

Simple Summary p53 is best known for its tumour suppressive functions mediated through
regulation of an extensive-gene regulatory network. Here we review progress in our …