Nitrite was once thought to have little physiological relevance. However, nitrite is now being
increasingly recognized as a therapeutic or possibly even physiological precursor of nitric …

The autocatalytic reaction between nitrite and the oxy form of globins involves free radicals.
For myoglobin (Mb), an initial binding of nitrite to the iron-coordinated oxygen molecule was …

The nitrite adducts of globins can potentially bind via O-or N-linkage to the heme iron. We
have used EPR (electron paramagnetic resonance) and DFT (density functional theory) to …

Recent data suggests that reactions of nitrite with ferric hemoglobin are potentially important
in heme-protein dependent NO signaling. Our group and others are evaluating the role of …

The chemical interplay of nitrogen oxides (NO's) with hemoglobin (Hb) has attracted
considerable recent attention because of its potential significance in the mechanism of NO …

Hemoglobin transports oxygen to the tissues of the body. The delivery of oxygen to tissues
by hemoglobin is dependent on blood flow, which is determined by vessel tension regulated …