[HTML][HTML] The function of sphingolipids in different pathogenesis of Alzheimer's disease: A comprehensive review

X Wang, H Li, Y Sheng, B He, Z Liu, W Li, S Yu… - Biomedicine & …, 2024 - Elsevier
Sphingolipids (SPLs) represent a highly diverse and structurally complex lipid class. The
discussion of SPL metabolism-related issues is of importance in understanding the …

Gastrointestinal dysfunction in neurological and neurodegenerative disorders

J Raber, TJ Sharpton - Seminars in neurology, 2023 - thieme-connect.com
Increasing research links the gut microbiome to neurodegenerative disorders. The gut
microbiome communicates with the central nervous system via the gut–brain axis and affects …

Effects of a high-fat diet on cognition and brain distribution of intranasal insulin in E3 and E4 male and female mice

A Chaklai, EM Rhea, A O'Niel, A Babin, R Weaver… - Scientific Reports, 2024 - nature.com
There are genetic and environmental risk factors that contribute to the development of
cognitive decline in Alzheimer's disease (AD). Some of these include the genetic …

Protective signature of xanthohumol on cognitive function of APP/PS1 mice: a urine metabolomics approach by age

W Liu, X Chen, J Zhao, C Yang, G Huang… - Frontiers in …, 2024 - frontiersin.org
Alzheimer's disease (AD) has an increasing prevalence, complicated pathogenesis and no
effective cure. Emerging evidences show that flavonoid compounds such as xanthohumol …

Effects of the ApoE genotype on cognitive function in aging mice fed with a high-fat diet and the protective potential of n-3 polyunsaturated fatty acids

X Zhang, T Xie, S Zhou, Y Yuan, W Chen, J Zheng… - Food & Function, 2024 - pubs.rsc.org
The ApoE4 allele is the strongest genetic determinant for Alzheimer's disease (AD), while
obesity is a strong environmental risk for AD. The modulatory effect of the ApoE genotype on …

[PDF][PDF] Xanthohumol improves cognition in farnesoid X receptor-deficient mice on a high-fat diet

P Kundu, IL Paraiso, J Choi… - Disease Models & …, 2022 - journals.biologists.com
Xanthohumol (XN) improves cognition of wild-type rodents on a high-fat diet (HFD). Bile
acids and ceramide levels in the liver and hippocampus might be linked to these effects. XN …

[PDF][PDF] Cognitive effects of Xanthohumol in wild-type and mutant mice lacking FXR in the intestine or liver on a high-fat diet

P Kundu, IL Paraiso, J Choi, CL Miranda… - Disease Models & …, 2022 - academia.edu
Cognitive effects of Xanthohumol in wild-type and mutant mice lacking FXR in the intestine or
liver on a high-fat diet Page 1 © 2022. Published by The Company of Biologists Ltd. This is an …