One of the major challenges of cardiovascular primary prevention approach is the absence
of early biomarkers of endothelial dysfunction which may be useful for identifying at-risk …

Despite impressive efforts invested in epigenetic research in the last 50 years, clinical
applications are still lacking. Only a few university hospital centers currently use epigenetic …

The risk of coronary heart disease (CHD) clinical manifestations and patient management is
estimated according to risk scores accounting multifactorial risk factors, thus failing to cover …

Despite the current reductionist approach providing an optimal indication for diagnosis and
treatment of patients with heart failure with reduced ejection fraction (HFrEF), there are no …

The lack of a precise stratification algorithm for predicting patients at high risk of graft
rejection challenges the current solid organ transplantation (SOT) clinical setting. In fact, the …

Atherosclerosis is a complex and multigenic pathology associated with significant epigenetic
reprogramming. Traditional factors (age, sex, obesity, hyperglycaemia, dyslipidaemia …

Background and aims DNA methylation is associated with gene silencing, but its clinical role
in cardiovascular diseases (CVDs) remains to be elucidated. We hypothesized that …

Objectives: Dilated cardiomyopathy (DCM) is characterized by a specific transcriptome.
Since the DCM molecular network is largely unknown, the aim was to identify specific …

Although decades of the reductionist approach achieved great milestones in optimizing the
immunosuppression therapy, traditional clinical parameters still fail in predicting both acute …

Epigenetic modifications play a fundamental role in the progression of coronary artery
disease (CAD). This panoramic review aims to provide an overview of the current …