An Updated View of the Trypanosoma cruzi Life Cycle: Intervention Points for an Effective Treatment

J Martín-Escolano, C Marín, MJ Rosales… - ACS Infectious …, 2022 - ACS Publications
Chagas disease (CD) is a parasitic, systemic, chronic, and often fatal illness caused by
infection with the protozoan Trypanosoma cruzi. The World Health Organization classifies …

Chagas disease: a silent threat for dogs and humans

J Durães-Oliveira, J Palma-Marques, C Moreno… - International Journal of …, 2024 - mdpi.com
Chagas disease (CD) is a vector-borne Neglected Zoonotic Disease (NZD) caused by a
flagellate protozoan, Trypanosoma cruzi, that affects various mammalian species across …

Mechanisms behind the high mortality rate in chronic Chagas cardiomyopathy: Unmasking a three‐headed monster

LE Echeverría, AY Serrano‐García… - European Journal of …, 2024 - Wiley Online Library
Chagas disease is a neglected tropical disease caused by the parasite Trypanosoma cruzi.
Chronic Chagas cardiomyopathy (CCC), the most severe form of target organ involvement in …

Outcomes of patients in Chagas disease of the central nervous system: a systematic review

WJ Shelton, JM Gonzalez - Parasitology, 2024 - cambridge.org
Chagas disease is a parasitic infection caused by the protozoan Trypanosoma cruzi. One of
the complications of the disease is the infection of the central nervous system (CNS), as it …

Hospitalizations due to gastrointestinal Chagas disease: National registry

AL Bierrenbach, ND Quintino… - PLoS neglected …, 2022 - journals.plos.org
Objectives Analyze the hospitalizations of patients admitted for Chagas disease with gastro-
intestinal involvement (CD-GI) in the Brazilian Unified Health System, describe the …

[HTML][HTML] A Multi-Epitope Protein for High-Performance Serodiagnosis of Chronic Chagas Disease in ELISA and Lateral Flow Platforms

ER Dias, AM Durans, BB Succar, LALT Pinto… - International Journal of …, 2024 - mdpi.com
We developed a protein to rapidly and accurately diagnose Chagas disease, a life-
threatening illness identified by the WHO as a critical worldwide public health risk …

Cancer and Trypanosoma cruzi: Tumor induction or protection?

PIR Franco, JR do Carmo Neto, MP Miguel… - Biochimie, 2023 - Elsevier
Trypanosoma cruzi causes Chagas disease, a neglected disease that can be divided,
overall, into acute and chronic phases. Understanding the mechanisms underlying its …

Subunit nanovaccine elicited T cell functional activation controls Trypanosoma cruzi mediated maternal and placental tissue damage and improves pregnancy …

LE Rios, N Lokugamage, S Choudhuri, IH Chowdhury… - npj Vaccines, 2023 - nature.com
This study investigated a candidate vaccine effect against maternal Trypanosoma cruzi (Tc)
infection and improved pregnancy outcomes. For this, TcG2 and TcG 4 were cloned in a …

[HTML][HTML] Network Analysis of Pathogenesis Markers in Murine Chagas Disease Under Antimicrobial Treatment

N Dias, M Dias, A Ribeiro, N Gomes, A Moraes… - Microorganisms, 2024 - mdpi.com
Chagas disease (CD), a disease affecting millions globally, remains shrouded in scientific
uncertainty, particularly regarding the role of the intestinal microbiota in disease …

[HTML][HTML] Molecular Markers for the Phylogenetic Reconstruction of Trypanosoma cruzi: A Quantitative Review

D Ramírez-Delgado, CA Flores-López - Pathogens, 2025 - mdpi.com
Trypanosoma cruzi is the parasite responsible for Chagas disease, which has a significant
amount of genetic diversification among the species complex. Many efforts are routinely …