Eph-Ephrin signaling mediates cross-talk within the bone microenvironment

A Arthur, S Gronthos - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
Skeletal integrity is maintained through the tightly regulated bone remodeling process that
occurs continuously throughout postnatal life to replace old bone and to repair skeletal …

RSK inhibitors as potential anticancer agents: discovery, optimization, and challenges

Y Sun, L Tang, C Wu, J Wang, C Wang - European Journal of Medicinal …, 2023 - Elsevier
Ribosomal S6 kinase (RSK) family is a group of serine/threonine kinases, including four
isoforms (RSK1/2/3/4). As a downstream effector of the Ras-mitogen-activated protein …

[HTML][HTML] Ephrin-A3/EphA2 axis regulates cellular metabolic plasticity to enhance cancer stemness in hypoxic hepatocellular carcinoma

A Husain, YT Chiu, KMF Sze, DWH Ho, YM Tsui… - Journal of …, 2022 - Elsevier
Background & Aims The highly proliferative nature of hepatocellular carcinoma (HCC)
frequently results in a hypoxic intratumoural microenvironment, which creates a therapeutic …

Regulation of the EphA2 receptor intracellular region by phosphomimetic negative charges in the kinase-SAM linker

BC Lechtenberg, MP Gehring, TP Light… - Nature …, 2021 - nature.com
Eph receptor tyrosine kinases play a key role in cell-cell communication. Lack of structural
information on the entire multi-domain intracellular region of any Eph receptor has hindered …

Tandem Mass Tagging-Based Quantitative Proteomics Analysis Reveals Damage to the Liver and Brain of Hypophthalmichthys molitrix Exposed to Acute Hypoxia …

X Li, C Feng, H Sha, T Zhou, G Zou, H Liang - Antioxidants, 2022 - mdpi.com
Aquaculture environments frequently experience hypoxia and subsequent reoxygenation
conditions, which have significant effects on hypoxia-sensitive fish populations. In this study …

A multiscale model via single-cell transcriptomics reveals robust patterning mechanisms during early mammalian embryo development

Z Cang, Y Wang, Q Wang, KWY Cho… - PLoS computational …, 2021 - journals.plos.org
During early mammalian embryo development, a small number of cells make robust fate
decisions at particular spatial locations in a tight time window to form inner cell mass (ICM) …

EphA2 and EGFR: friends in life, partners in crime. Can EphA2 be a predictive biomarker of response to anti-EGFR agents?

M Cioce, VM Fazio - Cancers, 2021 - mdpi.com
Simple Summary The Ephrin receptors and their ligands play important roles in organ
formation and tissue repair, by orchestrating complex programs of cell adhesion and …

Hypoxia-induced TGFBI maintains glioma stem cells by stabilizing EphA2

Z Chen, J Wang, P Peng, G Liu, M Dong… - …, 2024 - pmc.ncbi.nlm.nih.gov
Rationale: Glioma stem cells (GSCs) have emerged as pivotal drivers of tumor malignancy,
sustained by various microenvironmental factors, including immune molecules and hypoxia …

EPHA2 is a novel cell surface marker of OCT4-positive undifferentiated cells during the differentiation of mouse and human pluripotent stem cells

A Intoh, K Watanabe-Susaki, T Kato… - Stem Cells …, 2024 - academic.oup.com
Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) possess the
intrinsic ability to differentiate into diverse cellular lineages, marking them as potent …

ERK1/2‐RSK regulation of oestrogen homeostasis

EB Wright, DA Lannigan - The FEBS journal, 2023 - Wiley Online Library
The molecular mechanisms regulating oestrogen homeostasis have been primarily studied
in the mammary gland, which is the focus of this review. In the non‐pregnant adult, the …