A novel mixing rule model to predict the flowability of directly compressed pharmaceutical blends
In the pharmaceutical industry, powder flowability is an essential manufacturability attribute
to consider when selecting the suitable manufacturing route and formulation. The selection …
to consider when selecting the suitable manufacturing route and formulation. The selection …
[HTML][HTML] A hybrid system of mixture models for the prediction of particle size and shape, density, and flowability of pharmaceutical powder blends
M Salehian, J Moores, J Goldie, CM Torrecillas… - International Journal of …, 2024 - Elsevier
This paper presents a system of hybrid models that combine both mechanistic and data-
driven approaches to predict physical powder blend properties from their raw component …
driven approaches to predict physical powder blend properties from their raw component …
The Integration of Drug Substance and Drug Product Manufacturing Models: The Missing Link for Model-based End-to-End Process Development
Demonstrations of pharmaceutical process modelling have been made in the literature in
the pursuit of accelerated development. Modelling activities for drug substance (DS) and …
the pursuit of accelerated development. Modelling activities for drug substance (DS) and …
Direct Compression Flowsheet Modelling to Assess Tablet Manufacturability and In Vitro Dissolution
M Aroniada, C Christodoulou, H Khaled - Computer Aided Chemical …, 2023 - Elsevier
Direct Compression (DC) is a desirable manufacturing route for pharmaceutical tablets,
having fewer unit operations than granulation processes. Assessment of the impact of …
having fewer unit operations than granulation processes. Assessment of the impact of …