Proteins started being used as pharmaceuticals in the 1920s with insulin extracted from pig
pancreas. In the early 1980s, human insulin was prepared in recombinant bacteria and it is …

Transgenic animal bioreactors can produce therapeutic proteins with high value for
pharmaceutical use. In this paper, we compared different systems capable of producing …

Germline transgenesis is an important procedure for functional investigation of biological
pathways, as well as for animal biotechnology. We have established a simple, nonviral …

Uterine secretions, or histotroph, are a critical component for early embryo survival,
functioning as the sole supply of vitamins, minerals, enzymes, and other myriad of nutrients …

Background Intestinal inflammation produces an induction of alkaline phosphatase (AP)
activity that is attributable in part to augmented expression, accompanied by a change in …

Background and purpose The reliable assessment of proarrhythmic risk of compounds
under development remains an elusive goal. Current safety guidelines focus on the effects …

Alkaline phosphatase (AP) inactivates bacterial lipopolysaccharide and may therefore be
protective. The small intestine and colon express intestinal (IAP) and tissue nonspecific …

Transgenic rabbit is the preferred disease model of atherosclerosis, lipoprotein metabolism
and cardiovascular diseases since upon introducing genetic mutations of human genes …

Recombinant human proteins produced by the mammary glands of genetically modified
transgenic livestock mammals represent a special aspect of milk bioactive components. For …

The neonatal Fc receptor (FcRn) regulates IgG and albumin homeostasis, mediates
maternal IgG transport, takes an active role in phagocytosis, and delivers antigen for …