(1) Background: Colorectal cancer (CRC) is the third most common cancer and the second
leading cause of cancer-related mortality worldwide. Up to 50% of patients with CRC …

Current management of locally advanced rectal cancer achieves high cure rates, distant
metastatic spread being the main cause of patients' death. Total neoadjuvant therapy (TNT) …

The use of preoperative or “neoadjuvant” chemotherapy (NAC) has long been controversial
for resectable colorectal liver metastases (CRLM). The European Society of Medical …

Background A margin≥ 1 mm is considered a standard resection margin for colorectal liver
metastasis (CRLM). However, microscopic incomplete resection (R1) is not rare since …

Simple Summary This is a follow-up study of an international multicentric cohort after
minimally invasive liver resection (SIMMILR-1) from five international centers evaluating …

Simple Summary Colorectal cancer is a prevalent disease, often progressing to metastatic
stages. A subgroup of patients displaying oligometastases presents a unique opportunity for …

Background There is still debate regarding the principal role and ideal timing of
perioperative chemotherapy (CTx) for patients with upfront resectable colorectal liver …

Abstract Background Genetic And Morphological Evaluation (GAME) score is the newest
prognostic model for patient with colorectal liver metastases (CRLMs). Pathological and …

Background Anti–vascular endothelial growth factor (VEGF) agents have shown clinical
benefits against metastatic colorectal cancer (mCRC) when combined with cytotoxic …

Colorectal liver metastasis (CLM) occurs in a significant number of patients with colorectal
cancer. Over several decades, surgical methods and chemotherapy improved, making it …