Advance of sporadic Alzheimer's disease animal models
L Zhang, C Chen, MSH Mak, J Lu, Z Wu… - Medicinal research …, 2020 - Wiley Online Library
Abstract Alzheimer's disease (AD), the most common form of dementia, is a progressive
neurodegenerative disease. In the past decades, numbers of promising drug candidates …
neurodegenerative disease. In the past decades, numbers of promising drug candidates …
[HTML][HTML] Spatial proteomics in three-dimensional intact specimens
Spatial molecular profiling of complex tissues is essential to investigate cellular function in
physiological and pathological states. However, methods for molecular analysis of large …
physiological and pathological states. However, methods for molecular analysis of large …
Perspectives on primary blast injury of the brain: translational insights into non-inertial low-intensity blast injury
Most traumatic brain injuries (TBIs) during military deployment or training are clinically “mild”
and frequently caused by non-impact blast exposures. Experimental models were …
and frequently caused by non-impact blast exposures. Experimental models were …
Low-intensity open-field blast exposure effects on neurovascular unit ultrastructure in mice
Mild traumatic brain injury (mTBI) induced by low-intensity blast (LIB) is a serious health
problem affecting military service members and veterans. Our previous reports using a …
problem affecting military service members and veterans. Our previous reports using a …
Single-nucleus transcriptomic mapping of blast-induced traumatic brain injury in mice hippocampus
L Zhang, Q Yang, R Yuan, M Li, M Lv, L Zhang, X Xie… - Scientific Data, 2023 - nature.com
As a significant type of traumatic brain injury (TBI), blast-induced traumatic brain injury (bTBI)
frequently results in severe neurological and psychological impairments. Due to its unique …
frequently results in severe neurological and psychological impairments. Due to its unique …
Cerebrospinal fluid metabolomics identifies 19 brain-related phenotype associations
The study of metabolomics and disease has enabled the discovery of new risk factors,
diagnostic markers, and drug targets. For neurological and psychiatric phenotypes, the …
diagnostic markers, and drug targets. For neurological and psychiatric phenotypes, the …
Vascular injury is associated with repetitive head impacts and tau pathology in chronic traumatic encephalopathy
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease linked to repetitive
head impacts (RHI) and characterized by perivascular hyperphosphorylated tau (p-tau) …
head impacts (RHI) and characterized by perivascular hyperphosphorylated tau (p-tau) …
Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE ε2 protective effect in Alzheimer disease
Mechanisms underlying the protective effect of apolipoprotein E (APOE) ε2 against
Alzheimer disease (AD) are not well understood. We analyzed gene expression data …
Alzheimer disease (AD) are not well understood. We analyzed gene expression data …
An update on the association between traumatic brain injury and Alzheimer's disease: Focus on Tau pathology and synaptic dysfunction
L Li, J Liang, H Fu - Neuroscience & Biobehavioral Reviews, 2021 - Elsevier
Abstract LP Li, JW Liang and HJ Fu. An update on the association between traumatic brain
injury and Alzheimer's disease: Focus on Tau pathology and synaptic dysfunction …
injury and Alzheimer's disease: Focus on Tau pathology and synaptic dysfunction …
Brain-related proteins as serum biomarkers of acute, subconcussive blast overpressure exposure: a cohort study of military personnel
AM Boutte, B Thangavelu, CR LaValle, J Nemes… - PLoS one, 2019 - journals.plos.org
Repeated exposure to blast overpressure remains a major cause of adverse health for
military personnel who, as a consequence, are at a higher risk for neurodegenerative …
military personnel who, as a consequence, are at a higher risk for neurodegenerative …