Advances in nanomedicine, coupled with novel methods of creating advanced materials at
the nanoscale, have opened new perspectives for the development of healthcare and …

This article reviews the major physiological and physicochemical principles of the effect of
food and gastrointestinal (GI) pH on the absorption and bioavailability of oral drugs, and the …

Following studies in the late 1990s that indicated that poor pharmacokinetics and toxicity
were important causes of costly late-stage failures in drug development, it has become …

Introduction: Although significant progress has been made in high-throughput screening of
absorption, distribution, metabolism and excretion, and toxicity (ADME-Tox) properties in …

The objectives of the following investigation were (1) development of a physiologically
based pharmacokinetic (PBPK) model capable of characterizing the plasma and tissue …

We assess the advancement of physiologically based pharmacokinetic (PBPK) modeling
and simulation (M&S) over the last 20 years (start of 2000 to end of 2019) focusing on the …

Pectin-derived matrices are now being examined and tested for controlled drug delivery.
Pectin is intact in the upper gastrointestinal tract and degraded by colonic microflora. The …

Background: The Caco-2 monolayer has been used extensively for the high-throughput
screening of drug permeability and identification of substrates, inhibitors, and inducers of …

Measurement of drug solubility in various solvents is one of the key elements of compound
characterization during the whole discovery and development process. This review …

Purpose The purpose of this study was to develop a new system for computer simulation to
predict fraction absorbed (F a) of Biopharmaceutical Classification System (BCS) class II …