The inositol trisphosphate/calcium signaling pathway in health and disease
MJ Berridge - Physiological reviews, 2016 - journals.physiology.org
Many cellular functions are regulated by calcium (Ca2+) signals that are generated by
different signaling pathways. One of these is the inositol 1, 4, 5-trisphosphate/calcium …
different signaling pathways. One of these is the inositol 1, 4, 5-trisphosphate/calcium …
Mechanisms and physiological implications of cooperative gating of clustered ion channels
Ion channels play a central role in the regulation of nearly every cellular process. Dating
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …
Ca2+ signals initiate at immobile IP3 receptors adjacent to ER-plasma membrane junctions
NB Thillaiappan, AP Chavda, SC Tovey… - Nature …, 2017 - nature.com
Abstract IP3 receptors (IP3Rs) release Ca2+ from the ER when they bind IP3 and Ca2+. The
spatial organization of IP3Rs determines both the propagation of Ca2+ signals between …
spatial organization of IP3Rs determines both the propagation of Ca2+ signals between …
GM1-ganglioside accumulation at the mitochondria-associated ER membranes links ER stress to Ca2+-dependent mitochondrial apoptosis
R Sano, I Annunziata, A Patterson, S Moshiach… - Molecular cell, 2009 - cell.com
Mitochondria-associated ER membranes, or MAMs, define the sites of endoplasmic
reticulum/mitochondria juxtaposition that control Ca 2+ flux between these organelles. We …
reticulum/mitochondria juxtaposition that control Ca 2+ flux between these organelles. We …
IP3 receptors: toward understanding their activation
CW Taylor, SC Tovey - Cold Spring Harbor perspectives …, 2010 - cshperspectives.cshlp.org
Inositol 1, 4, 5-trisphosphate receptors (IP3R) and their relatives, ryanodine receptors, are
the channels that most often mediate Ca2+ release from intracellular stores. Their regulation …
the channels that most often mediate Ca2+ release from intracellular stores. Their regulation …
Inositol 1, 4, 5‐trisphosphate receptors and their protein partners as signalling hubs
Abstract Inositol 1, 4, 5‐trisphosphate receptors (IP3Rs) are expressed in nearly all animal
cells, where they mediate the release of Ca2+ from intracellular stores. The complex spatial …
cells, where they mediate the release of Ca2+ from intracellular stores. The complex spatial …
Dopamine and synaptic plasticity in dorsal striatal circuits controlling action selection
The striatum is thought to play a central role in learning how to choose acts that lead to
reward and avoid punishment. Dopamine-dependent modification of striatal synapses in the …
reward and avoid punishment. Dopamine-dependent modification of striatal synapses in the …
Spatiotemporal pattern of calcium activity in astrocytic network
A Semyanov - Cell calcium, 2019 - Elsevier
Ca 2+ influx through an astrocyte plasma membrane is mediated by ionotropic receptors
and Ca 2+ channels according the electrochemical gradient. These conductances allow …
and Ca 2+ channels according the electrochemical gradient. These conductances allow …
An NAADP-gated two-pore channel targeted to the plasma membrane uncouples triggering from amplifying Ca2+ signals
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a ubiquitous messenger
proposed to stimulate Ca 2+ release from acidic organelles via two-pore channels (TPCs). It …
proposed to stimulate Ca 2+ release from acidic organelles via two-pore channels (TPCs). It …
Biochemistry of calcium oscillations
Cytosolic calcium (Ca2+) oscillations are vastly flexible cell signals that convey information
regulating numerous cellular processes. The frequency and amplitude of the oscillating …
regulating numerous cellular processes. The frequency and amplitude of the oscillating …