Poly (ADP-ribose) polymerase inhibition: past, present and future
The process of poly (ADP-ribosyl) ation and the major enzyme that catalyses this reaction,
poly (ADP-ribose) polymerase 1 (PARP1), were discovered more than 50 years ago. Since …
poly (ADP-ribose) polymerase 1 (PARP1), were discovered more than 50 years ago. Since …
Cancer, metastasis, and the epigenome
S Kiri, T Ryba - Molecular Cancer, 2024 - Springer
Cancer is the second leading cause of death worldwide and disease burden is expected to
increase globally throughout the next several decades, with the majority of cancer-related …
increase globally throughout the next several decades, with the majority of cancer-related …
Beyond PARP1: the potential of other members of the poly (ADP-Ribose) polymerase family in DNA repair and cancer therapeutics
IA Richard, JT Burgess, KJ O'Byrne… - Frontiers in Cell and …, 2022 - frontiersin.org
The proteins within the Poly-ADP Ribose Polymerase (PARP) family encompass a diverse
and integral set of cellular functions. PARP1 and PARP2 have been extensively studied for …
and integral set of cellular functions. PARP1 and PARP2 have been extensively studied for …
A Focused DNA-Encoded Chemical Library for the Discovery of Inhibitors of NAD+-Dependent Enzymes
DNA-encoded chemical libraries are increasingly used in pharmaceutical research because
they enable the rapid discovery of synthetic protein ligands. Here we explored whether …
they enable the rapid discovery of synthetic protein ligands. Here we explored whether …
Nobiletin in cancer therapy: How this plant derived-natural compound targets various oncogene and onco-suppressor pathways
M Ashrafizadeh, A Zarrabi, S Saberifar, F Hashemi… - Biomedicines, 2020 - mdpi.com
Cancer therapy is a growing field, and annually, a high number of research is performed to
develop novel antitumor drugs. Attempts to find new antitumor drugs continue, since cancer …
develop novel antitumor drugs. Attempts to find new antitumor drugs continue, since cancer …
Fused in sarcoma (FUS) in DNA repair: tango with poly (ADP-ribose) polymerase 1 and compartmentalisation of damaged DNA
MV Sukhanova, AS Singatulina, D Pastré… - International Journal of …, 2020 - mdpi.com
The fused in sarcoma (FUS) protein combines prion-like properties with a multifunctional
DNA/RNA-binding domain and has functions spanning the regulation of RNA metabolism …
DNA/RNA-binding domain and has functions spanning the regulation of RNA metabolism …
A multi-task FP-GNN framework enables accurate prediction of selective PARP inhibitors
PARP (poly ADP-ribose polymerase) family is a crucial DNA repair enzyme that responds to
DNA damage, regulates apoptosis, and maintains genome stability; therefore, PARP …
DNA damage, regulates apoptosis, and maintains genome stability; therefore, PARP …
Genomic signatures of high-altitude adaptation in Ethiopian sheep populations
Background Ethiopian sheep populations such as Arsi-Bale, Horro and Adilo (long fat-tailed,
LFT) inhabit mid to high-altitude areas; and Menz sheep (MZ, short fat-tailed) are adapted to …
LFT) inhabit mid to high-altitude areas; and Menz sheep (MZ, short fat-tailed) are adapted to …
Structure-based design, synthesis, and evaluation of inhibitors with high selectivity for PARP-1 over PARP-2
J Yu, L Luo, T Hu, Y Cui, X Sun, W Gou, W Hou… - European Journal of …, 2022 - Elsevier
The poly (ADP-ribose) polymerase (PARP) inhibitors play a crucial role in cancer therapy.
However, most approved PARP inhibitors have lower selectivity to PARP-1 than to PARP-2 …
However, most approved PARP inhibitors have lower selectivity to PARP-1 than to PARP-2 …
Discovery of Quinazoline-2,4(1H,3H)-dione Derivatives Containing a Piperizinone Moiety as Potent PARP-1/2 Inhibitors─Design, Synthesis, In Vivo Antitumor …
J Zhou, T Du, X Wang, H Yao, J Deng, Y Li… - Journal of Medicinal …, 2023 - ACS Publications
PARP-1/2 inhibitors have become an important therapeutic strategy for the treatment of HR-
deficient tumors. However, discovery of new inhibitors with an improved and distinct …
deficient tumors. However, discovery of new inhibitors with an improved and distinct …