The influence of LINE‐1 and SINE retrotransposons on mammalian genomes
SR Richardson, AJ Doucet, HC Kopera… - Mobile DNA …, 2015 - Wiley Online Library
Transposable elements (TEs) or “jumping genes” historically have been disparaged as a
class of “junk DNA” in mammalian genomes (1, 2). The advent of whole genome DNA …
class of “junk DNA” in mammalian genomes (1, 2). The advent of whole genome DNA …
How retrotransposons shape genome regulation
Retrotransposons are mutagenic units able to move within the genome. Despite many
defenses deployed by the host to suppress potentially harmful activities of retrotransposons …
defenses deployed by the host to suppress potentially harmful activities of retrotransposons …
L1 drives IFN in senescent cells and promotes age-associated inflammation
Retrotransposable elements are deleterious at many levels, and the failure of host
surveillance systems for these elements can thus have negative consequences. However …
surveillance systems for these elements can thus have negative consequences. However …
LINE1 derepression in aged wild-type and SIRT6-deficient mice drives inflammation
Mice deficient for SIRT6 exhibit a severely shortened lifespan, growth retardation, and highly
elevated LINE1 (L1) activity. Here we report that SIRT6-deficient cells and tissues …
elevated LINE1 (L1) activity. Here we report that SIRT6-deficient cells and tissues …
Frequency and mechanisms of LINE-1 retrotransposon insertions at CRISPR/Cas9 sites
CRISPR/Cas9-based genome editing has revolutionized experimental molecular biology
and entered the clinical world for targeted gene therapy. Identifying DNA modifications …
and entered the clinical world for targeted gene therapy. Identifying DNA modifications …
Structures, functions and adaptations of the human LINE-1 ORF2 protein
ET Baldwin, T van Eeuwen, D Hoyos, A Zalevsky… - Nature, 2024 - nature.com
Abstract The LINE-1 (L1) retrotransposon is an ancient genetic parasite that has written
around one-third of the human genome through a 'copy and paste'mechanism catalysed by …
around one-third of the human genome through a 'copy and paste'mechanism catalysed by …
Affinity proteomics reveals human host factors implicated in discrete stages of LINE-1 retrotransposition
LINE-1s are active human DNA parasites that are agents of genome dynamics in evolution
and disease. These streamlined elements require host factors to complete their life cycles …
and disease. These streamlined elements require host factors to complete their life cycles …
Cell fitness screens reveal a conflict between LINE-1 retrotransposition and DNA replication
LINE-1 retrotransposon overexpression is a hallmark of human cancers. We identified a
colorectal cancer wherein a fast-growing tumor subclone downregulated LINE-1, prompting …
colorectal cancer wherein a fast-growing tumor subclone downregulated LINE-1, prompting …
Modulation of LINE-1 and Alu/SVA retrotransposition by Aicardi-Goutieres syndrome-related SAMHD1
Summary Long interspersed elements 1 (LINE-1) occupy at least 17% of the human genome
and are its only active autonomous retrotransposons. However, the host factors that regulate …
and are its only active autonomous retrotransposons. However, the host factors that regulate …
LINE-1 protein localization and functional dynamics during the cell cycle
LINE-1/L1 retrotransposon sequences comprise 17% of the human genome. Among the
many classes of mobile genetic elements, L1 is the only autonomous retrotransposon that …
many classes of mobile genetic elements, L1 is the only autonomous retrotransposon that …